Search for dissertations about: "prostaglandin E2"

Showing result 16 - 20 of 104 swedish dissertations containing the words prostaglandin E2.

  2. 16. Factors Contributing to Detrusor Overactivity - Obstruction, Hypertrophy and Afferent Nerve Stimulation

    Author : Annette Schröder; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; knockout; mice; estrogen receptor; EP1 receptor; prostaglandin; rat; endothelin; detrusor overactivity; rabbit; smooth muscle; bladder outlet obstruction; hypertrophy; pharmacognosy;

    Abstract : The consequences of bladder outlet obstruction (BOO) with respect to detrusor hypertrophy, structural and functional changes, and obstruction-induced detrusor overactivity were investigated in vivo and in vitro utilizing various animal models. Possible pathophysiological pathways and therapeutic approaches were tested by drug treatment and the use of knockout models. READ MORE

  4. 17. Molecular Mechanisms of Reward and Aversion

    Author : Anna Klawonn; David Engblom; Anders Blomqvist; Paul Kenny; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Motivation; Dopamine; Reward; Aversion; Negative affect; Systemic Inflammation; Drug Addiction; Cytokines; Prostaglandin E2; Melanocortin receptor 4; Acetylcholine; Muscarinic M4 receptor;

    Abstract : Various molecular pathways in the brain shape our understanding of good and bad, as well as our motivation to seek and avoid such stimuli. This work evolves around how systemic inflammation causes aversion; and why general unpleasant states such as sickness, stress, pain and nausea are encoded by our brain as undesirable; and contrary to these questions, how drugs of abuse can subjugate the motivational neurocircuitry of the brain. READ MORE

  5. 18. Prostaglandin E2 as mediator and modulator of airway smooth muscle responses

    Author : Jesper Säfholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostaglandin E2 (PGE2) is a lipid mediator produced by virtually every cell of the human body. Because common non-steroidal anti-inflammatory drugs (NSAIDs) inhibit its biosynthesis, PGE2 is usually considered to be a ‘pro-inflammatory’ mediator. The role of PGE2 in the lung and airways has however always been unclear. READ MORE

  6. 19. Talking to the Brain at the Blood-Brain Barrier through Inflammation-Induced Prostaglandin E2

    Author : Ana Maria Vasilache; Camilla Nilsberth; Sivert Lindström; Fredrik Elinder; Ted Ebendal; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The immune-to-brain signaling is a critical survival factor when the body is confronted by pathogens, and in particular by microorganisms. During infections, the ability of the immune system to engage the central nervous system (CNS) in the management of the inflammatory response is just as important as its ability to mount a specific immune response against the pathogen, since the CNS can provide a systemic negative feed-back to the immune activation by release of stress hormones and also can prioritize the usage of the energy resources by the vital organs. READ MORE

  7. 20. Role of prostaglandin E2 as a neuro-immune mediator in the cholinergic anti-inflammatory pathway

    Author : Priya Revathikumar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Therapeutic implications of cholinergic anti-inflammatory pathway (CAP) activation have marked the beginning of a novel treatment strategy of passing electrical impulses along the left vagus nerve to alleviate acute and chronic inflammatory conditions. Extensive work in understanding CAP through vagus nerve stimulation (VNS) have identified key molecular and cellular mechanisms involved in the α7 nicotinic acetylcholine receptor (nAChR) mediated control of inflammation. READ MORE