Search for dissertations about: "prostaglandin"

Showing result 11 - 15 of 202 swedish dissertations containing the word prostaglandin.

  1. 11. Novel therapy for neuroblastoma : focus on prostaglandin E2 and microsomal prostaglandin E synthases-1

    Author : Anna Kock; Karolinska Institutet; Karolinska Institutet; []

    Abstract : Cancer is a major public health problem and to date cancer is one of the leading causes of death worldwide. Neuroblastoma is a malignant pediatric tumor of the sympathetic nervous system. Neuroblastoma is one of the most common and deadliest extra cranial tumors of childhood. READ MORE

  2. 12. Cell signalling in cancer. A functional and immunochemical investigation of purinergic,adrenergic, nitrergic, and prostaglandin mediated signalling mechanisms in experimental and human cancer

    Author : Gunnar Nylund; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : ; adenosine-5´-triphosphate; colon cancer; extracellular acidification; melanoma; microphysiometer; nitric oxide; noradrenaline; prostaglandin E2; sarcoma; tumour cell; metabolism; uridine-5´-triphosphate;

    Abstract : Disturbed cell signalling is a hallmark of the cancer cell, being one important mechanismbehind uncontrolled cell growth. In the current study, we have investigated cancer cellsignalling with the focus on some first messenger and/or their receptors, in the murine celllines, MCG 101, and K1735-M2, and the human colon cancer cell line, HT-29. READ MORE

  3. 13. Prostaglandin E2 in immune-to-brain signaling

    Author : David Engblom; Tamas Bartfai; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Upon immune-challenge, signaling from the immune system to the brain triggers an array of central nervous responses that include fever, anorexia, hyperalgesia and activation of the hypothalamus-pituitary adrenal axis. These symptoms are dependent on cytokines produced at the site of inflammation. READ MORE

  4. 14. Palladium-promoted synthesis of compounds labelled with ¹¹C : Synthesis of ¹¹C-labelled prostacyclin and prostaglandin analogues

    Author : Margareta Björkman; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Abstract : Palladium-promoted reactions have been employed for the synthesis of compounds labelled with 11C (t½ = 20.3 min). The precursor [11C]methyl iodide was used in palladium-promoted cross-coupling reactions with organostannanes. READ MORE

  5. 15. Regulation of prostaglandin E2 synthesis in human gingival fibroblasts

    Author : Tülay Yucel-Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; prostaglandin E2; cyclooxygenase; phospholipase A2 interleukin-1; tumor necrosis factor [alpha]; epidermal growth factor; protein kinase C; tyrosine kinases; human gingival fibroblasts;

    Abstract : Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis. The aim of the present thesis was to study the production and the regulation of PGE2 with special reference to the key enzymes phospholipase A2 (PLA2) and cyclooxygenase (COX) at the rnRNA level in human gingival fibroblasts. READ MORE