Search for dissertations about: "prostaglandin"

Showing result 26 - 30 of 208 swedish dissertations containing the word prostaglandin.

  2. 26. The Role of Cyclooxygenase-2 in Models of Epilepsy and Traumatic Brain Injury : Effects of Selective Cyclooxygenase-2 Inhibitors

    Author : Tina Kunz; Tadeusz Wieloch; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Controlled cortical contusion injury; fluid percussion injury; limbic seizures; nuclear factor-kappa B; prostaglandin metabolism; TUNEL staining; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : Cyclooxygenase-2 (COX-2) catalyses prostaglandin synthesis from arachidonic acid during inflammation. COX-2 is expressed in the normal brain and is induced in neurological disorders. There is evidence that COX-2 is involved in secondary events leading to cell death in the brain. READ MORE

  4. 27. Characterization of human glutathione-dependent microsomal prostaglandin E synthase-1

    Author : Staffan Thorén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostaglandins (PGs) are lipid mediators, which act as local hormones. PGs are formed in most calls and are synthesized de novo from membrane-released arachidonic acid (AA) upon cell activation. READ MORE

  5. 28. Secretory activity in isolated rat stomach ECL cells

    Author : Erik Lindström; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; Calcium channels; Adrenaline; Pancreastatin; Prostaglandin E2; Galanin; Somatostatin; Histamine; Gastrin; VIP; PACAP; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : ECL cells are endocrine/paracrine cells located in the acid-producing part of the stomach. They are important regulators of gastric acid secretion in the stomach by virtue of their histamine synthesizing and secreting capacity. Histamine in turn stimulates parietal cells to secrete acid. READ MORE

  6. 29. Effects of low-load repetitive work and mental load on sensitising substances and metabolism in the trapezius muscle

    Author : Gerd Flodgren; Gisela Sjøgaard; Umeå universitet; []
    Keywords : work-related muscle pain; microdialysis; near-infrared spectroscopy; electromyography; glutamate; lactate; pyruvate; prostaglandin E2; norepinephrine; Occupational and Environmental Medicine; arbets- och miljömedicin;

    Abstract : Low-load repetitive work (LLRW) and mental load are important risk factors for the development of workrelated muscle pain. The link between these risk factors and the development of pain is still not understood, but stimulation of chemo-sensitive receptors in the muscle probably plays an important role. READ MORE

  7. 30. Dopamine D2 and D3 receptors. Studies on transduction mechanisms and on the role of a D3 gene polymorphism

    Author : Monika Hellstrand; Göteborgs universitet; []
    Keywords : dopamine; dopamine D2 receptor; dopamine D3 receptor; transduction; CHO cells; partial agonism; inverse agonism; arachidonic acid; prostaglandin E2; cAMP; haloperidol; -3-PPP; PNU-99194A; polymorphism; personality;

    Abstract : The neurotransmitter dopamine has been implicated in the pathophysiology of, e.g., Parkinson s disease and schizophrenia, and dopamine receptor-active compounds are commonly employed therapeutically in these and other disorders. READ MORE