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Showing result 1 - 5 of 49 swedish dissertations matching the above criteria.

  2. 1. Investigating the activation and regulation of the proteasome : an essential proteolytic complex

    Author : Patrick Masson; Patrick Young; Marcus Groettrup; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Proteasome; PA28gamma; Transcriptional regulation; Drosophila; 26S; Molecular biology; Molekylärbiologi;

    Abstract : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. READ MORE

  4. 2. Identification and characterization of a proteasome deubiquitinase inhibitor

    Author : Slavica Brnjic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The 26S proteasome has emerged as an attractive therapeutic target in the treatment of cancers. Proteasome inhibitors have been shown to selectively kill cancer cells. The FDA approval of bortezomib for the treatment of multiple myeloma and mantle cell lymphoma has clinically validated the 26S proteasome as a therapeutic target in oncology. READ MORE

  5. 3. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes

    Author : Johnny Sternesjö; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin secretion; cytokines; nitric oxide; streptozotocin; NOD mice; proteasome; nuclear factor-kappaB; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. READ MORE

  6. 4. Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity

    Author : Chao Sun; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of life. Development of 2nd generation proteasome inhibitors that could overcome these shortcomings is thus of prime medical importance. READ MORE

  7. 5. The ubiquitin-proteasome system during proteotoxic stress

    Author : Victoria Menéndez Benito; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ubiquitin; proteasome; green fluorescent protein GFP ; degradation; inhibitor; neurodegeneration; stress;

    Abstract : The dual function of the ubiquitin-proteasome system in protein quality control and as a master regulator of vital cellular processes places the system in a delicate position. This might be particularly relevant under patho-physiological conditions such as endoplasmic reticulum stress, which provoke the accumulation of aberrant proteins. READ MORE