Search for dissertations about: "proteasome inhibitor"

Showing result 11 - 15 of 49 swedish dissertations containing the words proteasome inhibitor.

  2. 11. Proteasome targeted therapy in arthritis models : effects on pain and inflammation

    Author : Aisha Siddiqah Ahmed; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The ubiquitin proteasome system (UPS) regulates numerous cellular functions by selectively degrading cellular proteins. It controls activation of the transcription factor NF-ĸB which is involved in the expression of pro-inflammatory mediators. The UPS regulates neuronal signalling by controlling levels of synaptic proteins during chronic pain. READ MORE

  4. 12. Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy

    Author : Magdalena Mazurkiewicz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, cell death, and cell cycle regulation. In comparison to cells in healthy tissues, cancer cells proliferate faster and have increased protein synthesis rate; therefore in order to preserve cellular fitness they are more dependent on UPS than normal cells. READ MORE

  5. 13. Proteasome inhibition in the regulation of natural killer cell function and multiple myeloma cell apoptosis

    Author : Xiaoli Feng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple myeloma (MM) is a hematologic malignancy mostly occurring in the elderly and characterized by an expansion of monoclonal plasma cells in the bone marrow and increased monoclonal immunoglobulin in plasma. The outcome of this disease has been greatly improved due to introduction of new drugs. READ MORE

  6. 14. Expression and function of vascular estrogen receptors alpha and beta

    Author : Min Liang; Kärlfysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetologi; diabetology; Endokrinologi; sekretion; ubiquitin-proteasome pathway; MIP-2; MCP-1; iNOS; estrogen receptor knockout; estrogen receptor; aorta; estrogen;

    Abstract : Estrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. READ MORE

  7. 15. Analysis and manipulation of autoreactive and tumor-specific T cell responses

    Author : Jelena Petrovic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Autoimmune Diabetes Mellitus; T cell immune response; proteasome inhibitor;

    Abstract : The focus of this work has been on the analysis and manipulation of T cell responses. One emphasis has been on T cells involved in autoimmune diabetes and another on T cells in tumor immunity. Primary activation of T cells as well as the role of the proteasome in T cell responses has been overlapping themes. READ MORE