Search for dissertations about: "proteasome inhibitor"

Showing result 21 - 25 of 49 swedish dissertations containing the words proteasome inhibitor.

  2. 21. Apoptosis signaling in leukemia and lymphoma: understanding mechanisms of chemoresistance

    Author : Astrid Ottosson Wadlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Apoptosis (programmed cell death) is a basic physiological process, essential in the balance between life and death of cells of normal tissues in the body. Apoptosis can be considered as cellular “suicide” initiated by the cell itself when infected by a virus or transformed into a cancer cell. READ MORE

  4. 22. Degradation and sequestration : cellular strategies to counteract proteotoxic stress

    Author : Shanshan Xu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Maintenance of proteome homeostasis (proteostasis) is essential to preserve cellular function in response to intrinsic and extrinsic stress conditions. This is regulated by the proteostasis network, which is comprised of machineries for protein synthesis, folding, sequestering, and degradation. READ MORE

  5. 23. Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs

    Author : Xin Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance includes two broad categories: intrinsic and acquired. READ MORE

  6. 24. Tipping the scales in cancer : novel mechanisms of inhibiting protein degradation

    Author : Tatiana A Giovannucci; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein homeostasis (in short, ‘proteostasis’) requires the timely degradation of proteins to retain control on protein quality, amount and function. Two main proteolytic systems, the ubiquitin-proteasome system (UPS) and autophagy, complement each other to fulfill this regulatory role. READ MORE

  7. 25. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action

    Author : Jenny Felth; Lars Bohlin; Joachim Gullbo; Ulf Göransson; Thomas Efferth; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic; cardiac glycoside; gambogic acid; cancer; mechanism of action; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

    Abstract : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. READ MORE