Search for dissertations about: "proteasome inhibitor"

Showing result 6 - 10 of 49 swedish dissertations containing the words proteasome inhibitor.

  2. 6. Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system

    Author : Ellin-Kristina Hillert; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, have been shown to have effective anti-cancer properties, verifying the UPS as a viable drug target in cancer treatment. READ MORE

  4. 7. Functional studies of the ubiquitin proteasome system using GFP based reporters

    Author : Kristina Lindsten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ubiquitin; proteasome; green fluorescent protein GFP ; degradation; inhibitor; Gly-Ala repeat; neurodegencration; poly-Gln aggregates.;

    Abstract : Ubiquitin-dependent proteasomal degradation is of paramount importance for cellular processes such as cell cycle progression, transcriptional regulation, apoptosis and disposal of misfolded and aberrant proteins. Moreover the ubiquitin-proteasome system is the main producer of peptides used by major histocompatibility complex class 1 for antigen presentation. READ MORE

  5. 8. Potential New Drugs in Lymphoma

    Author : Maryam Delforoush; Gunilla Enblad; Mattias Berglund; Christina Drott; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphoma; diffuse large B-cell lymphoma; DLBCL; picropodophyllin; PPP; J1; melflufen; prodrug; cancer therapeutics; alkylating agents; b-AP15; proteasome inhibitors; DUB inhibition; UCHL5; USP14;

    Abstract : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). READ MORE

  6. 9. Tumour Survival Signals and Epigenetic Gene Silencing in Multiple Myeloma : Implications for Biology and Therapy

    Author : Charlotte Fristedt Duvefelt; Helena Jernberg-Wiklund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; Polycomb; apoptosis; cIAP2; IAP-inbibitors; proteasome inhibitors; LBH589; PPP; DZNep;

    Abstract : This thesis is focused on multiple myeloma (MM), a haematological malignancy that still remains incurable. The pathogenesis of MM is not fully understood and there is a large intra-tumour and interclonal genetic variation in MM patients. READ MORE

  7. 10. Proteasome Inhibitors against Cancer: Determining Biology and Finding Novel Compounds

    Author : Arjan Mofers; Stig Linder; Padraig D´arcy; Sonia Lain; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer continues to be a tremendous burden on society in terms of loss of quality of life and life-years. The ubiquitin proteasome system (UPS), responsible for the bulk of protein turnover in the cell, is considered an attractive target in cancer therapy. READ MORE