Search for dissertations about: "proteasome"
Showing result 11 - 15 of 156 swedish dissertations containing the word proteasome.
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11. Nanoscopic adventures : unraveling macromolecular complexes in infectious diseases via integrative structural biology
Abstract : This thesis focuses on understanding the underlying molecular mechanisms of infectious diseases, which claim nearly 9 million lives annually. The research centers on critical analysis of pathogen mechanisms and drug resistance. I have mainly focused on two clades of pathogens: Enterococcus faecalis and microsporidia. E. READ MORE
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12. Neuron-to-neuron propagation of neurodegenerative proteins; relation to degradative systems
Abstract : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are defined by neurodegeneration and accumulations of misfolded proteins that spread through the brain in a well characterized manner. In AD these accumulations consist mainly of β-amyloid (Aβ) and tau, while in PD, α-synuclein (α-syn) make up the characteristic lewy pathology. READ MORE
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13. The interactome of the Epstein-Barr virus nuclear antigen 5 suggests novel roles in RNA and protein metabolism
Abstract : Epstein-Barr virus (EBV) is a human herpes virus that infects B and epithelial cells of the oropharynx. EBV is transmitted by saliva and establishes a lifelong latency in over 90% of the world's population. During latency, the virus exists predominantly as multicopy episomes in the nuclei of memory B cells. READ MORE
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14. Functional characterization of the human adenovirus pVII protein and non-coding VA RNAI
Abstract : Human adenovirus (HAdV) is a common pathogen causing a broad spectrum of diseases. HAdV encodes the pVII protein, which is involved in nuclear delivery, protection and expression of viral DNA. To suppress the cellular interferon (IFN) and RNA interference (RNAi) systems, HAdVs encode non-coding virus-associated (VA) RNAs. READ MORE
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15. Cellular Responses to Arsenite and Cadmium - Mechanisms of Toxicity and Defense in Saccharomyces cerevisiae
Abstract : All biological systems have to cope with a wide range of metals that are present in the environment. Metals can be essential or beneficial for life, inert or non-essential and toxic, often depending on their chemical form and concentration. Most organisms have evolved defense mechanisms in order to deal with toxic metals. READ MORE