Search for dissertations about: "protective factor"

Showing result 21 - 25 of 357 swedish dissertations containing the words protective factor.

2. 21. Apoptosis in the myelodysplastic syndromes : protective effect of G-CSF

   Author : Jan Schmidt-Mende; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Increased apoptosis of hematopoietic progenitor cells is a hallmark for the myelodysplastic syndromes (MDS), and one of the main reasons for the ineffective hematopoiesis and subsequent cytopenia characteristic for the disease. In particular in low risk MDS, such as refractory anemia (RA) and refractory anemia with ringed sideroblasts (RARS), severe transfusion-dependent anemia leading to constant fatigue and weakness and therefore reduced quality of life often constitutes the main clinical problem. READ MORE

4. 22. Epidemiological aspects of tuberculosis in Guinea-Bissau, West Africa

   Author : Per Gustafson; Enheten för infektionssjukdomar; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tuberculin skin test; Infections; Infektioner; survival; mortality; case fatality rate; risk factor; incidence; Guinea-Bissau; Africa; epidemiology; Mycobacterium tuberculosis; HIV-2; HIV-1; HIV; Tbc; Tuberculosis; TB;

   Abstract : Tuberculosis (TB) has plagued the humanity for several thousands of years. The bacteria causing TB is mainly spread from person to person as an aerosol transmission. It is estimated that one third of the world’s population is infected with the disease; about 10% of these will develop active TB during their lifetime. READ MORE

5. 23. Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor

   Author : Roman A McLellan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The vast number of human xenobiotic-metabolising enzymes display interindividual variability that can alter the disposition of any compound metabolised by these enzymes, including environmental chemicals and many clinically used drugs. Both genetic and non-genetic factors affect the levels and activities of these enzymes. READ MORE

6. 24. Inflammation and the Insulin-like Growth Factor System at Very Preterm Birth. Implications for Early Morbidity and Development

   Author : Ingrid Pupp; Lund Pediatrik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cord blood; brain injury; cytokines; cerebral palsy; child development; fresh frozen plasma; inflammation; preterm birth; insulin-like growth factor I;

   Abstract : The intention of this thesis was to evaluate the effects of inflammation at very preterm birth on subsequent morbidity, as well as on the neuro-protective IGF-system. Prospective clinical studies of very preterm infants constituted a base for the evaluation. READ MORE

7. 25. Unveiling the protective mechanisms of NOX2-derived ROS against autoimmune diseases

   Author : Huqiao Luo; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), pose a significant burden on society, affecting a considerable portion of the global population. Both SLE and RA are known to have a strong genetic component, with shared genetic predispositions such as neutrophil cytosolic factor 1 (NCF1), which encodes for a subunit of NADPH oxidase 2 (NOX2) complex. READ MORE