Search for dissertations about: "protein L"
Showing result 1 - 5 of 555 swedish dissertations containing the words protein L.
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1. Functional association networks for disease gene prediction
Abstract : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. READ MORE
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2. Structural Studies of Binding Proteins: Investigations of Flexibility, Specificity and Stability
Abstract : Binding proteins are present both in gram-negative and gram-positive bacteria. They are the recognition components of the ABC transport systems that transport different nutrients into the cell, and are in some cases also involved in chemotaxis. READ MORE
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3. Misfolded superoxide dismutase-1 in amyotrophic lateral sclerosis
Abstract : Amyotrophic lateral sclerosis (ALS) is a disease in which the motor neurons die in a progressive manner, leading to paralysis and muscle wasting. ALS is always fatal, usually through respiratory failure when the disease reaches muscles needed for breathing. Most cases are sporadic, but approximately 5–10% are familial. READ MORE
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4. Life will find a way : Structural and evolutionary insights into FusB and HisA
Abstract : How do microbes adapt to challenges from the environment? In this thesis, two distinct cases were examined through structural and biochemical methods. In the first, we followed a real-time protein evolution of HisA to a novel function. The second case was fusidic acid (FA) resistance mediated by the protein FusB in Staphylococcus aureus. READ MORE
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5. SOD1 prions transmit templated aggregation and fatal ALS-like disease
Abstract : Amyotrophic lateral sclerosis (ALS) is an adult-onset fatal neurodegenerative disease characterized by a progressive degeneration of the upper and lower motor neurons. The resulting paresis begins focally, usually in one muscle, and spreads contiguously, leading to muscle wasting, progressive paralysis and eventually death. READ MORE