Search for dissertations about: "protein aggregation"
Showing result 21 - 25 of 323 swedish dissertations containing the words protein aggregation.
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21. SOD1 prions transmit templated aggregation and fatal ALS-like disease
Abstract : Amyotrophic lateral sclerosis (ALS) is an adult-onset fatal neurodegenerative disease characterized by a progressive degeneration of the upper and lower motor neurons. The resulting paresis begins focally, usually in one muscle, and spreads contiguously, leading to muscle wasting, progressive paralysis and eventually death. READ MORE
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22. Protein folding studies of human superoxide dismutase and ALS associated mutants
Abstract : Proteins are among the most abundant biological macromolecules. The cellular machinery is coupled to exact structural shape and properties of the more than 100 000 different proteins. Still, proteins can sometimes completely change their character and as a result trigger neuro degenerative disease. READ MORE
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23. Amyloid Beta – Biotherapy Target and Biotechnological Tool
Abstract : Alzheimer’s disease is a progressive neurodegenerative disease characterized primarily by memory impairment and cognitive decline. As of 2020, an estimated 50 million people suffer from Alzheimer’s disease or related dementia and no disease-modifying treatment options are yet approved for clinical practice. READ MORE
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24. Development of 2-Pyridone-based central fragments : Affecting the aggregation of amyloid proteins
Abstract : There are many applications of small organic compounds, e.g. as drugs or as tools to study biological systems. Once a compound with interesting biological activity has been found, medicinal chemists typically synthesize small libraries of compounds with systematic differences to the initial “hit” compound. READ MORE
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25. Metal release from stainless steel and CoCrMo alloys in protein-rich environments – effects of protein aggregation, friction, and irradiation
Abstract : Highly corrosion-resistant alloys are used in sensitive environments such as the human body and food environments. However, even tiny amounts of released metals from these surfaces could potentially cause adverse effects. It is hence important to study the biointerface between corrosion-resistant alloys and protein-rich environments. READ MORE