Search for dissertations about: "protein attachment"

Showing result 1 - 5 of 152 swedish dissertations containing the words protein attachment.

  2. 1. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions

    Author : Andreas Larsson; Jan Kihlberg; Fredrik Almqvist; Mats Larhed; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Antibacterial; pili; antiadhesive agents; structure based design; statistical molecular design; 2-pyridone; amino acid derivative; galabiose; enaminone; SPR; ELISA; QSAR; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. READ MORE

  4. 2. Development of Novel Macrocyclic Inhibitors of Protein-Protein Interactions : Applied to the Keap1-Nrf2 Complex

    Author : Fabio Begnini; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Abstract : .... READ MORE

  5. 3. Cell-protein-material Interactions on Bioceramics and Model Surfaces

    Author : Åsa Rosengren; Sven Oscarsson; Lucy Di Silvio; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; protein adsorption; blood proteins; biomaterials; ceramics; glass-ceramics; two-dimensional gel electrophoresis; protein orientation; silicon wafers; atomic force microscopy; bone cell adhesion; divalent cation dependency; Kemi; Chemistry; Kemi;

    Abstract : The objective of this thesis was to investigate and characterize the interaction between blood proteins and different surfaces with emphasis on protein adsorption to bioceramics and model surfaces. Special effort was made to monitor the spontaneous and selective adsorption of proteins from human plasma and to examine the orientation, conformation and functional behavior of single proteins after adsorption. READ MORE

  6. 4. Protein and Cell Interactions with Nanostructured Surfaces

    Author : Emma Westas; Chalmers tekniska högskola; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; bacteria; titanium dioxide; implant associated infections; metabolomics; cellular interactions; hydroxyapatite; immune complement activation; silica; nanoparticles; photocatalysis; protein adsorption; Nanostructured implants;

    Abstract : A great challenge of today’s implant development is to construct a surface that promotes tissue integration and avoids bacterial colonization. To avoid implant related infections, many argue that a surface promoting strong cell adhesion and tissue integration in favour for bacterial adhesion would solve the problem, the so-called race for the surface concept. READ MORE

  7. 5. Investigations into the evolution of biological networks

    Author : Sara Light; Arne Elofsson; David Ussery; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; evolution; scale-free network; metabolism; protein-protein interactions; protein hubs; Theoretical chemistry; Teoretisk kemi;

    Abstract : Individual proteins, and small collections of proteins, have been extensively studied for at least two hundred years. Today, more than 350 genomes have been completely sequenced and the proteomes of these genomes have been at least partially mapped. The inventory of protein coding genes is the first step toward understanding the cellular machinery. READ MORE