Search for dissertations about: "protein based computer"

Showing result 1 - 5 of 104 swedish dissertations containing the words protein based computer.

  2. 1. Unlocking protein sequences : Advances in protein structure and ligand-binding site prediction

    Author : Aditi Shenoy; Arne Elofsson; Geoffrey J Barton; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : The protein sequence determines how it will fold into its unique three-dimensional structure. Once folded, proteins perform their functions by interacting with other proteins or molecules called ligands within the cell. Experimental determination of protein structure and function is tedious. READ MORE

  4. 2. Structural Information and Hidden Markov Models for Biological Sequence Analysis

    Author : Jeanette Tångrot; Bo Kågström; Uwe H. Sauer; Erik Sonnhammer; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HMM; structure alignment; protein structure; secondary structure; remote homologue; annotation; domain family; protein family; protein superfamily; protein fold recognition; Bioinformatics; Bioinformatik;

    Abstract : Bioinformatics is a fast-developing field, which makes use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins, which is often based on finding relationships to already characterized proteins. READ MORE

  5. 3. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function

    Author : Pierre Matricon; Jens Carlsson; Bjørn Olav Brandsdal; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Dynamics Simulations; Free Energy Perturbation; Ligand Binding; Fragment-Based Lead Discovery; Molecular Docking Screens; Homology Modeling; GPCR Activation Mechanism; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. READ MORE

  6. 4. Learning predictive models from graph data using pattern mining

    Author : Thashmee M. Karunaratne; Henrik Boström; Lars Asker; Nada Lavraˇc; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Machine Learning; Graph Data; Pattern Mining; Classification; Regression; Predictive Models; Computer and Systems Sciences; data- och systemvetenskap;

    Abstract : Learning from graphs has become a popular research area due to the ubiquity of graph data representing web pages, molecules, social networks, protein interaction networks etc. However, standard graph learning approaches are often challenged by the computational cost involved in the learning process, due to the richness of the representation. READ MORE

  7. 5. Transmembrane Proteins and Protein Structure Prediction : What we can learn from Computational Methods

    Author : John Lamb; Arne Elofsson; Paolo Marcatili; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; contact prediction; transmembrane protein; topology prediction; machine learning; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : A protein’s 3D-structure is essential to understand how proteins function and interact and how biochemical processes proceed in organic life. Despite the advancement in experimental methods, it remains expensive and time-consuming to determine protein structure experimentally. READ MORE