Search for dissertations about: "protein c"

Showing result 1 - 5 of 1657 swedish dissertations containing the words protein c.

  1. 1. Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Huddinge

    Author : Samuel C. C. Chiang; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cytotoxic lymphocytes encompass natural killer (NK) cells and cytotoxic T lymphocytes (CTL). These cells detect and kill virus-infected as well as malignant cells. Primary defects in lymphocyte cytotoxicity are associated with development of a hyperinflammatory syndrome termed hemophagocytic lymphohistiocytosis (HLH). READ MORE

  2. 2. Computational Protein Evolution Modeling the Selectivity and Promiscuity of Engineered Enzymes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Klaudia Szeler; Shina C. Lynn Kamerlin; Mikael Widersten; Maria Ramos; [2020]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzymes; kinetics; catalysis; density functional theory; empirical valence bond; diesters; evolution; promiscuity; Biokemi; Biochemistry;

    Abstract : Enzymes are biological catalysts that significantly increase the rate of all biochemical reactions that take place within cells and are essential to maintain life. Many questions regarding their function remain unknown. READ MORE

  3. 3. Modelling the Protein-DNA Interface

    University dissertation from Uppsala : Uppsala University

    Author : Malin Lüking; Shina C. Lynn Kamerlin; Ehmke Pohl; [2020]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-DNA interactions; Molecular Dynamics; Coarse-grained simulations; gene regulation; Biokemi; Biochemistry;

    Abstract : Protein-DNA interactions are crucial to life. Several millions of DNA base pair steps are organ- ised, read and protected by proteins in every cell. Protein-DNA interactions must be specific, controllable and reasonably fast. Understanding how these features coexist is one of the great challenges for biochemists and molecular biologists. READ MORE

  4. 4. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Malin C Lagerström; Uppsala universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Classification; Structure; Pharmacology; Evolution; G protein-coupled receptor; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. READ MORE

  5. 5. Anticoagulant protein C--structural and functional studies

    University dissertation from Department of Clinical Chemistry, Lund University

    Author : Lei Shen; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymology; Proteins; Klinisk kemi; Clinical chemistry; serpins; membrane binding; factor V; protein C; protein S; Proteiner; enzymologi;

    Abstract : Anticoagulant protein C is a vitamin K-dependent factor circulating in plasma as a zymogen of a serine protease. It is converted to its active form (APC) by the thrombin-thrombomodulin complex on the surface of endothelial cells. APC inhibits the generation of thrombin by selective proteolytic inactivation procoagulant factors Va and VIIIa. READ MORE