Search for dissertations about: "protein c"

Showing result 1 - 5 of 1603 swedish dissertations containing the words protein c.

  1. 1. Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Huddinge

    Author : Samuel C. C. Chiang; Karolinska Institutet.; Karolinska Institutet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cytotoxic lymphocytes encompass natural killer (NK) cells and cytotoxic T lymphocytes (CTL). These cells detect and kill virus-infected as well as malignant cells. Primary defects in lymphocyte cytotoxicity are associated with development of a hyperinflammatory syndrome termed hemophagocytic lymphohistiocytosis (HLH). READ MORE

  2. 2. Tools and annotations for variation

    University dissertation from Lund University, Faculty of Medicine

    Author : Gerard C.P. Schaafsma; Lunds universitet.; Lund University.; [2017]
    Keywords : Annotation; genetic variation; benchmarks; databases; disease groups; pathogenicity; proteins; representativeness; sensitivity; variant effect analysis;

    Abstract : Since the finishing of the Human Genome Project, many next-generation (NGS) or high-throughput sequencing platforms have emerged. One of the applications of NGS technology, variant discovery, can serve as a basis for precision medicine. READ MORE

  3. 3. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Malin C Lagerström; Uppsala universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Classification; Structure; Pharmacology; Evolution; G protein-coupled receptor; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. READ MORE

  4. 4. Anticoagulant protein C--structural and functional studies

    University dissertation from Department of Clinical Chemistry, Lund University

    Author : Lei Shen; Lunds universitet.; Lund University.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymology; Proteins; Klinisk kemi; Clinical chemistry; serpins; membrane binding; factor V; protein C; protein S; Proteiner; enzymologi;

    Abstract : Anticoagulant protein C is a vitamin K-dependent factor circulating in plasma as a zymogen of a serine protease. It is converted to its active form (APC) by the thrombin-thrombomodulin complex on the surface of endothelial cells. APC inhibits the generation of thrombin by selective proteolytic inactivation procoagulant factors Va and VIIIa. READ MORE

  5. 5. Advances in Membrane Protein Structural Biology: Lipidic Sponge Phase Crystallization, Time-Resolved Laue Diffraction and Serial Femtosecond Crystallography

    University dissertation from Department of Clinical Chemistry, Lund University

    Author : Linda C Johansson; Göteborgs universitet.; Gothenburg University.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Serial femtosecond crystallography; Lipidic sponge phase crystallization; Membrane protein crystallization; X-ray free-electron laser;

    Abstract : Membrane proteins carry out many essential tasks in cells such as signaling and transport, or function as electron carriers in photosynthesis and cellular respiration. The aim of this thesis has been to develop new and improve existing techniques for elucidating the structure and function of membrane proteins. READ MORE