Search for dissertations about: "protein crystallization"

Showing result 6 - 10 of 62 swedish dissertations containing the words protein crystallization.

  2. 6. Engineering of Antibacterial Phage-Derived Proteins

    Author : Fredrik Seijsing; Anders Nilsson; Yves Briers; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein engineering; endolysin; IgG; linker protein; chimeric protein; artificial opsonin; spider silk; antibacterial surface; bacteriophage; structure prediction; molekylär biovetenskap; Molecular Bioscience;

    Abstract : The increasing threat of antibiotic resistance calls for the development of new treatment methods. Bacteriophages are interesting candidates since they can lyse bacteria with great efficiency. Bacteriophages produce enzymes called endolysins which break down the peptidoglycan in the cell wall at the end of the infection cycle. READ MORE

  4. 7. Structural and functional properties of transthyretin

    Author : Anders Karlsson; A. Elisabeth Sauer-Eriksson; Salam Al-Karadaghi; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Amyloidosis; X-ray crystallography; Protein structure; Protein; Structural biology; Strukturbiologi;

    Abstract : The hereditary transthyretin (TTR) amyloidoses are rare, and in severe cases, fatal disorders caused by mutations in the TTR gene. The clinical picture is diverse, involving neuropathies and myopathies, and mainly depends on the causative mutation and the sites and rates of amyloid deposition. READ MORE

  5. 8. Identification of SLiMs: Mapping and characterizing motif-based protein interactions

    Author : Muhammad Ali; Ylva Ivarsson; Shoshana Wodak; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Phage display; protein-protein interactions; short linear motifs; PDZ; FERM; affinity; x-ray crystallization; molecular docking; NLS;

    Abstract : During the last twenty years it has become evident that about 35-40% of amino acids in the proteome are in regions that have evolved to remain unstructured. These intrinsically disordered regions contain short linear motifs (SLiMs), which serve as docking sites for protein-protein interactions. READ MORE

  6. 9. Statistical processing of Flash X-ray Imaging of protein complexes

    Author : Alberto Pietrini; Carl Nettelblad; Johan Bielecki; Janos Hajdu; Flavio Capotondi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray; XFEL; single particle; hit-finder; statistical hit-finder; single protein; protein complex; RNA polymerase II; FEL; free-electron laser; FXI; Flash X-ray Imaging; CXI; CSPAD; x-ray imaging; COACS; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Abstract : Flash X-ray Imaging (FXI) at X-ray Free Electron Lasers (XFELs) is a promising technique that permits the investigation of the 3D structure of molecules without the need for crystallization, by diffracting on single individual sample particles.In the past few years, some success has been achieved by using FXI on quite large biological complexes (40 nm-1 μm in diameter size). READ MORE

  7. 10. Advances in Membrane Protein Structural Biology: Lipidic Sponge Phase Crystallization, Time-Resolved Laue Diffraction and Serial Femtosecond Crystallography

    Author : Linda C Johansson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Serial femtosecond crystallography; Lipidic sponge phase crystallization; Membrane protein crystallization; X-ray free-electron laser;

    Abstract : Membrane proteins carry out many essential tasks in cells such as signaling and transport, or function as electron carriers in photosynthesis and cellular respiration. The aim of this thesis has been to develop new and improve existing techniques for elucidating the structure and function of membrane proteins. READ MORE