Search for dissertations about: "protein denaturation"

Showing result 6 - 10 of 54 swedish dissertations containing the words protein denaturation.

2. 6. Towards First-Principles Understanding of Biomolecular Adsorption

   Author : Svetla Chakarova Käck; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; DFT; phenol; adenine; graphite; biomolecules; van der Waals interactions; denaturation; protein; lattice models; PAH dimers; adsorption;

   Abstract : A fundamental understanding of the interactions of biomolecules, such as proteins and DNA, with surfaces is of immense importance in numerous applications and poses a true challenge for theory. Density functional theory (DFT) is a quantum-mechanical tool well established for its ability to balance large system size with good accuracy in first-principles studies. READ MORE

4. 7. Protein unfolding by interfaces and interactions between polycyclic aromatic hydrocarbons

   Author : Svetla Chakarova Käck; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; first-principles calculations; PAH; denaturation; protein-interface interactions; van der Waals interactions; lattice models; polycyclic aromatic hydrocarbons; DFT; density functional theory;

   Abstract : In order to theoretically study large and complex systems, a variety of approaches that can be categorized loosely as top-down or bottom-up are followed. While our vision is to bridge the gap between these approaches and use them together in multiscale materials modeling, the present thesis is limited to give examples of each type of approach in the study of soft-matter systems. READ MORE

5. 8. Transthyretin and the transthyretin-related protein: A structural study

   Author : Erik Lundberg; A. Elisabeth Sauer-Eriksson; Lennart Sjölin; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Transthyretin-related protein; X-ray crystallography; Protein structure; Amyloidosis; Structural biology; Strukturbiologi;

   Abstract : Transthyretin (TTR) is one of several proteins involved in amyloid disease in humans. Unknown conformational changes of the native state of TTR result in aggregation of TTR molecules into amyloid fibrils, which accumulate in extracellular tissues. This may result in different clinical symptoms, e.g. READ MORE

6. 9. Protein engineering for biophysical studies of protein folding, stability and surface interactions

   Author : Martin Karlsson; Mikael Oliveberg; Linköpings universitet; []
   Keywords : Biochemistry; protein folding; NATURAL SCIENCES; NATURVETENSKAP;

   Abstract : The subject of this thesis can be split into two parts, one that is dealing with the stability and stabilization of proteins on its own merits and a second part that deals with the protein adsorption orientation on solid surfaces and how the stability of a protein influences the behavior at a solid/liquid interface. Thus, the common denominator and focus have been on protein stability. READ MORE

7. 10. Protein stabilization. Some methods and mechanisms

   Author : Maria Andersson; Bioteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; sorbitol; protein stability; preferential exclusion; polyol; poly-NIPAAm; polymer; poly ethyleneimine ; polyelectrolyte; oxidation; NMR spectroscopy; lysozyme; lactate dehydrogenase; fluorescence; dynamic light scattering; complex; additive; circular dichroism; stabilization; trypsin; thermo-reversible polymer.; Biotechnology; Bioteknik;

   Abstract : The effect of different additives on protein stability was studied, and the basis for stabilization was investigated at molecular level. The addition of sorbitol enhanced thermal stability of hen egg white lysozyme in aqueous solution. READ MORE