Search for dissertations about: "protein drug formulation"

Showing result 1 - 5 of 14 swedish dissertations containing the words protein drug formulation.

2. 1. Rational and combinatorial protein engineering for vaccine delivery and drug targeting

   Author : Maria Wikman; Stefan Ståhl; Carl A. K. Borrebaeck; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; affibody; affinity chromatography; biotin; combinatorial; delivery; phage display; Biomedicin; Microbiology; Mikrobiologi;

   Abstract : This thesis describes recombinant proteins that have been generated by rational and combinatorial protein engineering strategies for use in subunit vaccine delivery and tumor targeting.In a first series of studies, recombinant methods for incorporating immunogens into an adjuvant formulation, e.g. READ MORE

4. 2. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels

   Author : Yuxuan Zhuang; Erik Lindahl; Grace Brannigan; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ion channels; molecular dynamics; markov state model; lipid modulation; nicotinic receptor; protein conformational transitions; Biophysics; biofysik;

   Abstract : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. READ MORE

5. 3. Group B streptococci and other neonatal infections

   Author : Elisabet Persson; Göteborgs universitet; []
   Keywords : Neonatal infections; sepsis; incidence; ; Group B streptococcus; ; serotype; ; epidemiology; ; genotype; ; surface protein; ; antibiotic susceptibility;

   Abstract : The main objectives of this thesis were to estimate the incidence and etiology of invasive infections in neonates and to characterize invasive strains of group B streptococci from a defined geographic area. All infants aged 0-120 days with a bacterial or fungal isolate from blood or CSF in the defined area were identified. READ MORE

6. 4. Polymeric Nanoparticles as Carriers for Antimicrobial Peptides : Factors Affecting Peptide and Membrane Interactions

   Author : Randi Nordström; Martin Malmsten; Per Hansson; Helena Bysell; Erica Wanless; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antimicrobial peptide; microgel; degradable; nanogel; drug delivery; PEGylation; secondary structure; model membrane; lipid bilayer; neutron reflectometry; ellipsometry; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

   Abstract : As resistance towards conventional antibiotics is becoming more pronounced, cationic antimicrobial peptides (AMPs) have received considerable attention as possible therapeutic alternatives. Thousands of potent AMPs occur in humans, animals, plants and fungi as a natural part of the immune system. READ MORE

7. 5. The Horizontal Ussing Chamber Method in Studies of Nasal Drug Delivery : Method Development and Applications Using Different Formulations

   Author : Karin Östh; Anna-Lena Ungell; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

   Abstract : The results from this thesis leads to the following conclusions; HUM is a useful tool that fills a gap in the in vitro methods previously available to study nasal drug delivery. Using HUM, the pig respiratory nasal mucosa can obtain acceptable viability and retain it longer than the period of time needed for a transport experiment. READ MORE