Search for dissertations about: "protein fold recognition"

Showing result 1 - 5 of 38 swedish dissertations containing the words protein fold recognition.

  2. 1. Structural Information and Hidden Markov Models for Biological Sequence Analysis

    Author : Jeanette Tångrot; Bo Kågström; Uwe H. Sauer; Erik Sonnhammer; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HMM; structure alignment; protein structure; secondary structure; remote homologue; annotation; domain family; protein family; protein superfamily; protein fold recognition; Bioinformatics; Bioinformatik;

    Abstract : Bioinformatics is a fast-developing field, which makes use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins, which is often based on finding relationships to already characterized proteins. READ MORE

  4. 2. Structural Transitions in Helical Peptides : The Influence of Water – Implications for Molecular Recognition and Protein Folding

    Author : Martin Lignell; Hans-Christian Becker; Kaare Teilum; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein dynamics; protein folding; molten globule; time-resolved fluorescence spectroscopy; CD spectroscopy; molecular recognition; structure-function paradigm; Chemical physics; Kemisk fysik; Physical Chemistry; Fysikalisk kemi;

    Abstract : Fluctuations in protein structure are vital to function. This contrasts the dominating structure-function paradigm, which connects the well-defined three-dimensional protein structure to its function. However, catalysis is observed in disordered enzymes, which lack a defined structure. READ MORE

  5. 3. The use of structural information to improve biological sequence similarity searches

    Author : Jeanette Tångrot; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatik; Hidden Markov Model; HMM; protein structure alignment; protein structure superimposition; remote homologue; FISH-server; protein annotation; Bioinformatics; Bioinformatik;

    Abstract : Bioinformatics is a fast-developing field that make use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins. To determine the structure of a protein is a crucial part in the characterisation of the molecule. READ MORE

  6. 4. Development of molecular recognition by rational and combinatorial engineering

    Author : Andreas Jonsson; Stefan Ståhl; Mats Persson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; albumin binding domain; protein engineering; phage display; amyloid beta peptide; TNF; HSA; Molecular biology; Molekylärbiologi;

    Abstract : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. READ MORE

  7. 5. The ADAPT scaffold as a tool for diagnostic imaging and targeted therapy

    Author : Emma von Witting; Sophia Hober; Inger Sandlie; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein G; ABD; ADAPT; affinity proteins; antibody; protein engineering; targeted therapy; nuclear medicine; molecular imaging; HER2; radionuclide therapy; Bioteknologi; Biotechnology;

    Abstract : Molecular recognition, or the specific interactions between a protein and its ligand, is central to biology and a key factor for many different clinical and technical applications. Despite antibodies being only one of many different affinity proteins, it has by far been the most successful. READ MORE