Search for dissertations about: "protein formulation"

Showing result 1 - 5 of 58 swedish dissertations containing the words protein formulation.

2. 1. Spray-Dried Powders for Inhalation : Particle Formation and Formulation Concepts

   Author : Jessica Elversson; Göran Alderborn; Anna Millqvist-Fureby; Lars Hovgaard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Spray drying; Particle formation; Density; Protein formulation; Encapsulation; Coating; Competitive adsorption; Polymer; ESCA; AFM; FTIR; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Abstract : Spray drying is a method with a high potential in the preparation of protein particles suitable for pulmonary delivery. However, surface induced denaturation of bio-molecules during atomization and subsequent drying can be substantial and it is therefore important to develop new formulation concept for concurrent encapsulation and stabilization of proteins during spray drying. READ MORE

4. 2. Membrane protein topogenesis

   Author : Karin Öjemalm; Gunnar von Heijne; Tracy Palmer; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

   Abstract : The membranes of cells are highly complex and heterogeneous structures that fulfill multiple vital tasks. They form thin barriers that seal out the environment, thus defining the cell’s boundaries. READ MORE

5. 3. Combinatorial protein engineering applied to enzyme catalysis and molecular recognition

   Author : Malin Eklund; KTH; []
   Keywords : phage display; selection; enzyme; affinity domains; crystal structure; affibody; lipase; protein engineering; protein A; assembly;

   Abstract : The recent development of methods for constructing andhandling large collections (libraries) of proteins, from whichvariants with desired traits can be isolated, hasrevolutionized the field of protein engineering. Key elementsof such methods are the various ways in which the genotypes(the genes) and the phenotypes (the encoded proteins) arephysically linked during the process. READ MORE

6. 4. Engineering of Human Fetal Hemoglobin

   Author : Karin Kettisen; Tillämpad biokemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; fetal hemoglobin; protein engineering; recombinant protein production; protein purification; chromatography; oxygen carrier; redox reactions; net surface charge; DNA cleavage;

   Abstract : In blood, the oxygen-transporting protein hemoglobin (Hb) governs the oxygenation of cells and tissues. Naturally, this protein has claimed a place in the center of the research field of artificial oxygen therapeutics. READ MORE

7. 5. Protein Mixture Inference as Hitting Set Variants and Linear Algebra Problems

   Author : Leonid Molokov; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Union Editing; Shotgun proteomics; Parameterized complexity; Protein Inference; Shared Peptides; Set Cover; Hypergraph; Hitting Set; Fixed Parameter Tractable; Protein Quan- ti; Star Editing;

   Abstract : This work is dedicated to the problems of protein inference and quantification in bottom-up proteomics, and, in particular, in shotgun proteomics. We adopt a rather classical approach of representing inference problem as a set cover, where proteins are understood as sets of their observations: peptides' masses or sequences. READ MORE