Search for dissertations about: "protein hubs"

Showing result 1 - 5 of 12 swedish dissertations containing the words protein hubs.

2. 1. Investigations into the evolution of biological networks

   Author : Sara Light; Arne Elofsson; David Ussery; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; evolution; scale-free network; metabolism; protein-protein interactions; protein hubs; Theoretical chemistry; Teoretisk kemi;

   Abstract : Individual proteins, and small collections of proteins, have been extensively studied for at least two hundred years. Today, more than 350 genomes have been completely sequenced and the proteomes of these genomes have been at least partially mapped. The inventory of protein coding genes is the first step toward understanding the cellular machinery. READ MORE

4. 2. The Epstein-Barr nuclear antigens 1 & 5; Study of virus-host cellular protein interactions

   Author : Alma Forsman; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; EBNA1; EBNA5; EBNA-LP; cellular network; virus-host protein interactions;

   Abstract : The Epstein-Barr virus (EBV) is the causative agent or cofactor in the aetiology of several human malignancies such as Burkitt’s lymphoma, Hodgkin’s disease, nasopharyngeal carcinoma (NPC) and lymphoproliferative disorder in immunocompromised patients. EBV is a lymphotropic γ-herpes virus infecting more than 90 percent of the population worldwide. READ MORE

5. 3. Evolution and Binding Mechanisms of Intrinsically Disordered Proteins

   Author : Elin Karlsson; Per Jemth; Kaare Teilum; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intrinsically disordered proteins; Protein evolution; Binding kinetics; Binding mechanisms; Biophysical characterisation; Medicinsk biokemi; Medical Biochemistry;

   Abstract : Intrinsically disordered proteins (IDPs) make up a considerable fraction of the proteome in eukaryotic organisms. These proteins often act as hubs in interaction networks, harbouring multiple interaction with other proteins, and thus evolution has to walk a tightrope to accommodate new interactions while maintaining the previously established interactions. READ MORE

6. 4. The Epigenetics of Gene Transcription and Higher Order Chromatin Conformation

   Author : Vijay Kumar Tiwari; Rolf Ohlsson; Terumi Kohwi-Shigematsu; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; DNA-protein interactions; Nuclear organization; Transcriptional regulation; Higher order chromatin conformations; Epigenetic reprogramming; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

   Abstract : It is becoming increasingly clear that long-range control of gene expression is mediated through direct physical interactions between genes and regulatory elements, either intra- or interchromosomally. In addition to transcriptional initiation, formation of active chromatin hubs seem to be crucial for increased transcriptional efficiency as well as insulation from neighbouring heterochromatic environment. READ MORE

7. 5. From oncogenic replication stress to drug resistance : F-box proteins as signalling hubs in cancer

   Author : Andrä Brunner; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cancer arises from cells that acquire genetic and epigenetic changes during the course of a, sometimes decades-long, somatic evolutionary process. These changes result in deregulation of a multitude of cellular processes leading to novel capabilities, often referred to as hallmarks of cancer, and a strong selective advantage for these cells albeit at a dramatic cost to the organism as a whole. READ MORE