Search for dissertations about: "protein hydration"

Showing result 1 - 5 of 36 swedish dissertations containing the words protein hydration.

  1. 1. Protein-water interactions studied by molecular dynamics simulations

    Author : Filip Persson; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MD simulations; NMR nuclear magnetic resonance ; MRD; water dynamics; protein dynamics; protein hydration; Amide hydrogen exchange; Internal water; compressibility;

    Abstract : Most proteins have evolved to function optimally in aqueous environments, and the interactions between protein and water therefore play a fundamental role in the stability, dynamics, and function of proteins. Although we understand many details of water, we understand much less about the protein-water interface. READ MORE

  2. 2. Foreign molecules in biomembranes : Molecular effects on intact stratum corneum and model lipid systems

    Author : Quoc Dat Pham; Fysikalisk kemi; []
    Keywords : stratum corneum; lipid; keratin filament; protein; DMPC; penetration enhancer; osmolyte; solvent; monoterpene; fatty acid; hydration; molecular mobility; fluidity; permeability; PT ssNMR; diffusion cell;

    Abstract : This thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular information. READ MORE

  3. 3. Water and Protein Dynamics in Biological Systems Studied by Magnetic Relaxation Dispersion

    Author : Erik Persson Sunde; Biofysikalisk kemi; []
    Keywords : protein dynamics; ubiquitin; BPTI; Escherichia coli; Haloarcula marismortui; nuclear magnetic resonance; protein hydration; magnetic relaxation dispersion; water dynamics; cell water;

    Abstract : The results presented in this thesis demonstrate that the magnetic relaxation dispersion (MRD) technique can provide information of relevance to protein biophysics, magnetic resonance imaging and cell biology. By immobilizing proteins with covalent cross-links, intermittent protein dynamics on the previously inaccessible ns-µs time scale could be probed with MRD via the exchange of water molecules between internal cavities and the surrounding bulk solvent phase. READ MORE

  4. 4. Gas-Phase Protein Structure Under the Computational Microscope : Hydration, Titration, and Temperature

    Author : Erik Marklund; David van der Spoel; Albert Heck; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Molecular dynamics; gas phase; proteins; micelles; proton transfer; Grothuss mechanism; kinetics; Physics; Fysik; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Abstract : Although the native environment of the vast majority of proteins is a complex aqueous solution, like the interior of a cell, many analysis methods for assessing chemical and physical properties of biomolecules require the sample to be aerosolized; that is, transferred to the gas-phase. An important example is electrospray-ionization mass spectrometry, which can provide a wide range of information about e. READ MORE

  5. 5. The Role of Sugars for Protein Stabilization

    Author : Christoffer Olsson; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; NATURAL SCIENCES; protein; water; QENS; biomolecule; EPSR; amorphous; trehalose; neutron scattering; cryopreservation; DSC; neutron diffraction; dielectric spectroscopy;

    Abstract : The understanding of biomolecular interactions with water and co-solutes can lead to greater knowledge regarding the mechanisms behind biomolecular stabilization. This is highly important for developing technologies aimed to preserve biological materials. READ MORE