Search for dissertations about: "protein hydration"

Showing result 21 - 25 of 38 swedish dissertations containing the words protein hydration.

  2. 21. Skin hydration - How water and osmolytes influence biophysical properties of stratum corneum

    Author : Sebastian Björklund; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Stratum corneum; diffusive transport; permeability; flow-through cell; Franz cell; transdermal drug delivery; water activity; vapor pressure; osmotic gradient; relative humidity; ceramide; free fatty acid; cholesterol; keratin filaments; natural moisturizing factor NMF ; urea; glycerol; molecular mobility; 13C natural-abundance solid-state NMR; polarization transfer; isothermal calorimetry; impedance spectroscopy; X-ray diffraction;

    Abstract : The outermost layer of skin (i.e., the stratum corneum, SC) is the interface that separates the water-rich inside of the body from the relatively dry external environment. SC forms an effective permeability barrier, which has to be overcome in transdermal drug delivery. READ MORE

  4. 22. Self-Assembly in Lipid-Protein Systems : Lung Surfactant, Stratum Corneum and Model Membranes

    Author : Jenny Andersson; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lipid self-assembly; lung surfactant; stratum corneum; dehydrin; cholesterol; osmolytes; urea; TMAO; ssNMR; cSAXS;

    Abstract : This thesis explores lipid self-assembly and aims to give a broad picture of self-assembly structures in simple and complex lipid-protein systems. The systems studied are lung surfactant, stratum corneum and simple model membranes. The lung surfactant mixture lines the alveolus in our lungs and stabilises the air- tissue interface. READ MORE

  5. 23. Assessment of Computational Methods for Ligand Binding

    Author : Paulius Mikulskis; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; binding affinities; MM GBSA; MM PBSA; LIE; FEP; TI; BAR; protein-ligand complexes; drug design;

    Abstract : Most drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. READ MORE

  6. 24. On the estimation of ligand binding affinities

    Author : Samuel Genheden; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; binding affinities protein-ligand complexes; host-guest complexes; MM GBSA; MM PBSA; LIE; PDLD s-LRA; alchemical methods; sampling; solvation; drug design;

    Abstract : A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. READ MORE

  7. 25. Structural studies of bio-molecules and lipid assemblies using polarized light spectroscopy

    Author : Maxim Kogan; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; linear dichroism; lipid membrane; spectroscopy; ruthenium complex; phospholipids; DNA breathing;

    Abstract : The focus of the research presented in this thesis is structural studies of biological macromolecules using Linear Dichroism (LD) spectroscopy. The first part covers the flow alignment and structure of DMPC/DHPC phospholipid aggregates. READ MORE