Search for dissertations about: "protein kinase A"
Showing result 1 - 5 of 908 swedish dissertations containing the words protein kinase A.
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1. The choreography of protein vibrations : Improved methods of observing and simulating the infrared absorption of proteins
Abstract : The work presented in this thesis has striven toward improving the capability to study proteins using infrared (IR) spectroscopy. This includes development of new and improved experimental and theoretical methods to selectively observe and simulate protein vibrations. READ MORE
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2. The Adenovirus L4-33K Protein : A Key Regulator of Virus-specific Alternative Splicing
Abstract : Adenoviruses have been extensively studied in the field of gene regulation, since their genes are subjected to a tightly controlled temporal expression during the virus lifetime. The early-to-late shift in adenoviral gene expression distinguishes two completely different programs in gene expression. READ MORE
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3. Revealing Secrets of Synaptic Protein Interactions : A Biosensor based Strategy
Abstract : Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. READ MORE
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4. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells
Abstract : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. READ MORE
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5. Myosin 1c taking adrenergic metabolism for a spin : More than a motor protein
Abstract : Metabolic diseases like type II diabetes (T2D) and obesity largely stems from an unbalanced energy homeostasis with the fails of the insulin pathway to the point in which the glucose homeostasis is severely disturbed leading to hyperglycemia. We have investigated if the β-adrenergic signaling pathways, in both brown adipose tissue (BAT) and skeletal muscle, could be used as a strategy to alleviate metabolic disease. READ MORE