Search for dissertations about: "protein phosphatase-1"

Showing result 1 - 5 of 13 swedish dissertations containing the words protein phosphatase-1.

  2. 1. Studies on Phosphohistidine Phosphatase 1 : What? Where? Why?

    Author : Ulla Beckman Sundh; Pia Ek; Örjan Zetterqvist; Jin-ping Li; Christian Hedberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHPT1; Phosphohistidine phosphatase; PHP; Assay; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Phosphohistidine phosphatase 1 (PHPT1) is a small protein, consisting of 125 amino acids, that catalyzes the dephosphorylation of histidine but does not have any activity towards other phosphorylated amino acids. PHPT1 was identified in 2002, and is so far the only mammalian histidine phosphatase known, but still little is known about its physiological role. READ MORE

  4. 2. Role of DARPP-32 in Breast Cancer Cell Signalling and Migration

    Author : Christian Hansen; Molekylär neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell migration; protein phosphatase 1.; DARPP-32; breast cancer; protein kinase A;

    Abstract : Breast cancer is the most common form of cancer in women. While the prognosis for breast cancer patients without local or distal dissemination is relatively favorable, the prognosis is considerably worse once distal metastasis has been established. READ MORE

  5. 3. Regulation of Na+,K+-ATPase activity by protein phosphatase-1 and protein kinase C : studies in infant and adult renal tissue and on vascular smooth muscle cells

    Author : Dailin Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Na ; K -ATPase; phosphorylation; protein kinase C; protein phosphatase-1; arachidonic acid metabolites; ontogeny;

    Abstract : Na+, K+-ATPase is short-term modulated by hormones, involving activation of signal transduction system. The present study was designed to elucidate the role of the signaling molecules PP-1, PKC and arachidonic acid (AA) metabolites in the regulation of Na+, K+-ATPase by reversible phosphorylation, the final step of the signal transduction, and to examine the ontogeny of the signaling system. READ MORE

  6. 4. Structural and Functional Studies of the Density Enhanced Receptor-like Protein Tyrosine Phosphatase DEP-1

    Author : Maria Sörby; Jeroen Hertog; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Tyrosine phosphorylation is a central mechanism in cellular signalling leading to proliferation, migration or differentiation. Protein tyrosine phosphorylation is regulated by the coordinated actions of protein tyrosine kinases and protein tyrosine phosphatases. READ MORE

  7. 5. Transcriptional regulation of the latent membrane protein 1 gene by Epstein-Barr virus nuclear antigen 2

    Author : Lars Palmqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; B-cell; transformation; LMP1; EBNA2; transcription; phosphorylation; histone acetylation;

    Abstract : The Epstein-Barr virus (EBV) is a ubiquitous human herpes virus, which infects B-cells. This leads to a life-long latent infection, which in most cases is non-pathogenic. However, EBV is etiologically associated with several human malignancies, including endemic Burkitt's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoma. READ MORE