Search for dissertations about: "protein profile"

Showing result 1 - 5 of 400 swedish dissertations containing the words protein profile.

  1. 1. Protein structure prediction : Zinc-binding sites, one-dimensional structure and remote homology

    Author : Nanjiang Shu; Sven Hovmöller; Bruce Donald; Geoff Barton; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; zinc-binding; profile; homology detection; shape string; Bioinformatics; Bioinformatik; Molecular biology; Molekylärbiologi; Biochemistry; Biokemi; strukturkemi; Structural Chemistry;

    Abstract : Predicting the three-dimensional (3D) structure of proteins is a central problem in biology. These computationally predicted 3D protein structures have been successfully applied in many fields of biomedicine, e.g. family assignments and drug discovery. READ MORE

  2. 2. From protein sequence to structural instability and disease

    Author : Lixiao Wang; Uwe Sauer; Sven Hovmöller; Umeå universitet; []
    Keywords : protein domain; remote homologue; intrinsically disorder unstructured proteins; protein function; point mutation; protein family protein stability; HMMs; CRFs; SVMs;

    Abstract : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. READ MORE

  3. 3. Membrane and secretory protein production in Escherichia coli

    Author : Alexandros Karyolaimos; Jan-Willem de Gier; Matthew DeLisa; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; recombinant protein; tunable protein production; cytoplasmic membrane; periplasm; signal peptide; force profile analysis; co-translational folding; biokemi; Biochemistry;

    Abstract : Escherichia coli (E. coli) is the most widely used bacterium for the production of recombinant proteins. However, the production of proteins in its cytoplasmic membrane or periplasm is challenging. Therefore, the aim of this doctoral thesis was to develop setups for enhancing the production of membrane and secretory proteins in E. READ MORE

  4. 4. Protein isolation from herring (Clupea harengus) using the pH-shift process - Protein yield, protein isolate quality and removal of food contaminants

    Author : Sofia Marmon; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; LANTBRUKSVETENSKAPER; NATURAL SCIENCES; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; AGRICULTURAL SCIENCES; precipitation; acid; gelation; in vitro digestion; solubilization; herring; protein; salt solubility; pH; lipids; alkaline; transmission electron microscopy; dioxins;

    Abstract : Herring (Clupea harengus) contain valuable proteins but is difficult to process into high-quality foods due to its small size and high content of bones, heme-proteins and lipids. Herring is among the most abundant fish species in the world, but is currently utilized largely for fish meal and oil production. READ MORE

  5. 5. Systems Biology of Protein Secretion in Human Cells: Multi-omics Analysis and Modeling of the Protein Secretion Process in Human Cells and its Application

    Author : Rasool Saghaleyni; Chalmers University of Technology; []
    Keywords : Erythropoietin; cancer protein secretory pathway; protein secretion modeling; HEK293; protein secretion; Integrative omics analysis; genome-scale modeling;

    Abstract : Since the emergence of modern biotechnology, the production of recombinant pharmaceutical proteins has been an expanding field with high demand from industry. Pharmaceutical proteins have constituted the majority of top-selling drugs in the pharma industry during recent years. READ MORE