Search for dissertations about: "protein profile"

Showing result 11 - 15 of 439 swedish dissertations containing the words protein profile.

2. 11. Proximity Ligation and Barcoding Assays : Tools for analysis of proteins and protein complexes

   Author : Di Wu; Masood Kamali-Moghaddam; Ulf Landegren; Ola Söderberg; Jörg Hoheisel; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; proximity barcoding assay; sensitive; in situ; multiplex; profiling; amyloid-beta; MARK; tau; CSF; biomarker; protein complexes; Alzheimer’s disease; amyotrophic lateral sclerosis; Molekylär medicin; Molecular Medicine;

   Abstract : Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of proteins, such as by measuring their concentrations, characterizing their modifications, and detecting their interactions, provides insights in how biological systems work physiologically or pathologically at the molecular level. READ MORE

4. 12. Protein expression in prostate cancer

   Author : Helena Lexander; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Two-dimensional gel electrophoresis; protein expression; biomarker; Gleason grade; DNA-ploidy;

   Abstract : The molecular pathology of prostate cancer (PCa) is complex and the pathways and the acquired molecular defects responsible for PCa initiation, development and progression are still largely unknown. Tumors of the prostate have an unpredictable behavior and in clinically detected cancers it is presently not possible to assess tumor aggressiveness. READ MORE

5. 13. Molecular characterization of the hepatitis C virus core protein

   Author : Priya Devi; Anders Bergqvist; Björn Olsen; Tanel Punga; Gerald McInerney; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HCV; core protein; SHP-1; CpG methylation; bisulfite sequencing; NGS; PBMC; Ca2 NFAT; strand-specific RT qPCR; Klinisk virologi; Clinical Virology; Infektionssjukdomar; Infectious Diseases; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

   Abstract : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. READ MORE

6. 14. Bax and oxidized phospholipids - a deadly complex : Apoptotic protein-lipid assemblies studied by MAS NMR spectroscopy

   Author : Artur Dingeldein; Gerhard Gröbner; Mikael Elofsson; Tobias Sparrman; Daniel Topgaard; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; mitochondrial membranes; apoptosis; membrane dynamics and organization; Bcl-2 family proteins; Bax protein; biokemi; Biochemistry;

   Abstract : Mitochondria are renowned for their vital role as cellular powerhouses because they provide ATP via cellular respiration. Additionally, these organelles also play an important role in other physiological processes, such as apoptosis. READ MORE

7. 15. Sequence-based predictions of membrane-protein topology, homology and insertion

   Author : Andreas Bernsel; Gunnar von Heijne; Volkhard Helms; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; membrane protein; topology prediction; hidden markov model; homology detection; Sec translocon; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

   Abstract : Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide variety of biochemical pathways. Apart from their general biological significance, membrane proteins are of particular interest to the pharmaceutical industry, being targets for more than half of all available drugs. READ MORE