Search for dissertations about: "protein profiling"

Showing result 11 - 15 of 258 swedish dissertations containing the words protein profiling.

  2. 11. Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum

    Author : Kimi Drobin; Jochen M. Schwenk; Peter Nilsson; Ulrika Qundos; Angela Silveira; Maria Pernemalm; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; affinity proteomics; immunoassay; antibody microarray; suspension bead array; protein profiling; plasma; serum; biomarker discovery; osteoporosis; inflammatory bowel disease; Crohn s disease; ulcerative colitis; Medical Technology; Medicinsk teknologi;

    Abstract : Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. READ MORE

  4. 12. Multiplexed antibody-based protein profiling in the pursuit of CSF biomarkers for neurodegenerative diseases

    Author : Sofia Bergström; Peter Nilsson; Anna Månberg; Markus Otto; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Protein profiling; suspension bead array; cerebrospinal fluid; biomarker discovery; proteomics; Bioteknologi; Biotechnology;

    Abstract : There is a desire for a transition from generic treatments designed for the average patient, towards more individual-based precision medicine. An increased knowledge about disease pathophysiology on a molecular level would be beneficial for this transition. READ MORE

  5. 13. High-resolution phenotypic profiling of a eukaryotic ribosome

    Author : Jonathan Esguerra; Göteborgs universitet; []
    Keywords : ribosome; ribosomal protein genes; box C D snoRNA; box H ACA snoRNA; 2’-O-ribose methylation; pseudouridylation; high-resolution phenotypic profiling; chemogenetic profiling; Saccharomyces cerevisiae; rRNA modification;

    Abstract : All living cells contain ribosomes, complex macromolecular assemblies of ribonucleic acid (RNA) and proteins, responsible for synthesizing polypeptides in a process called translation. High-resolution three-dimensional ribosomal structures coupled with biochemical studies have paved the way in understanding the various mechanistic events during protein synthesis. READ MORE

  6. 14. Protein Expression Profiling of Cancer Biomarkers

    Author : Kristina Magnusson; Fredrik Pontén; Karin Jirström; Anna Dimberg; Tibor Tot; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody-based proteomics; Biomarker; SATB2; Colorectal cancer; ANLN; Breast cancer; CD93; Angiogenesis; Pathology; Patologi;

    Abstract : The Human Protein Atlas project is a Swedish research initiative that uses antibody-based proteomics for large scale protein profiling in human tissues and cells. Affinity-purified antibodies are produced within the project and used for immunohistochemical staining on tissue micro arrays (TMAs) in order to map the human proteome and publish the result in a protein atlas (www. READ MORE

  7. 15. Understanding the Noise : Spliceosomal snRNA Profiling

    Author : Lei Liu Conze; Anders Virtanen; Lars Wieslander; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; high-throughput sequencing; 454; SNP; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The concept of the gene has been constantly challenged by new discoveries in the life sciences. Recent challenging observations include the high frequency of alternative splicing events and the common transcription of non-protein-coding-RNAs (ncRNAs) from the genome. The latter has long been considered noise in biological systems. READ MORE