Advanced search

Showing result 1 - 5 of 138 swedish dissertations matching the above criteria.

  2. 1. On the role of actin in yeast protein quality control

    Author : Lisa Larsson Berglund; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein quality control; Actin; Protein aggregate; Segregation; Polarisome; CCT; Huntingtin;

    Abstract : Every cell is equipped with a protein quality control system to ensure the proper function of proteins. This is essential for both cell maintenance and the generation of new and healthy cells. READ MORE

  4. 2. Adaptation and Protein Quality Control Under Metalloid Stress

    Author : Sebastian Ibstedt; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein quality control; arsenite; tellurite; natural selection; Saccharomyces cerevisiae;

    Abstract : Toxic metals and metalloids are emerging as major environmental pollutants, having ecological consequences as well as being linked to a broad range of degenerative conditions in animals, plants and humans. While the toxicity of several metalloids is well established, the underlying molecular mechanisms are often not clear. READ MORE

  5. 3. Exploring small heat shock protein chaperones by crosslinking mass spectrometry

    Author : Wietske Lambert; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cross-linking; mass spectrometry; protein-protein interactions; Hsp21; BS3; DTSSP; MALDI-TOF TOF; client protein; substrate; aggregation; unfolded protein; chaperone; Small heat shock protein; crosslinking;

    Abstract : Together with other molecular chaperones, small heat shock proteins are key components of the protein quality control system, which is comprised of several hundred proteins and acts to maintain proteome homeostasis in the cell. Small heat shock proteins bind unfolding proteins at an early stage, to prevent these from further unfolding and aggregating. READ MORE

  6. 4. The interactome of the yeast mitochondrial ribosome : Organization of mitochondrial post-transcriptional regulation, membrane protein insertion and quality control

    Author : Braulio Vargas Möller-Hergt; Martin Ott; Michal Minczuk; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial post-transcriptional regulation; mitochondrial ribosome; membrane protein insertion; mitochondrial quality control; Biochemistry; biokemi;

    Abstract : The proteins found in mitochondria originate from two different genetic systems. Most mitochondrial proteins are synthesized in the cytosol and post-translationally imported into the organelle. However, a small subset of mitochondrial proteins is encoded in an organelle-resident genome. READ MORE

  7. 5. On chaperone co-operation in temporal and spatial protein quality control

    Author : Rebecca Andersson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular chaperones; Heat shock proteins; Hsp70 chaperones; Proteostasis; Ageing; Asymmetric damage segregation; Peroxiredoxins; Spatial protein quality control;

    Abstract : In order for a protein to be able to function correctly it needs to adopt its proper fold. Because of this, protein quality control (PQC) is vital at every level of cellular function. The central protein in PQC networks across all kingdoms of life are the Hsp70 molecular chaperones. READ MORE