Search for dissertations about: "protein structures"

Showing result 1 - 5 of 693 swedish dissertations containing the words protein structures.

  1. 1. Molecular principles of protein stability and protein-protein interactions

    University dissertation from Stockholm : KTH

    Author : Christofer Lendel; KTH.; [2005]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; binding thermodynamics; induced fit; molten globule; NMR spectroscopy; protein engineering; protein-protein interactions; protein stability; protein structure.; TECHNOLOGY Bioengineering Structural biochemistry; TEKNIKVETENSKAP Bioteknik Strukturbiokemi;

    Abstract : Proteins with highly specific binding properties constitute the basis for many important applications in biotechnology and medicine. Immunoglobulins have so far been the obvious choice but recent advances in protein engineering have provided several novel constructs that indeed challenge antibodies. READ MORE

  2. 2. Protein complexes assembly, structure and function

    University dissertation from Umeå : Umeå university

    Author : Kristina Wilhelm; Umeå universitet.; [2009]
    Keywords : HAMLET; ELOA; lysozyme; amyloid; Medical Biochemistry; medicinsk biokemi;

    Abstract :  Most proteins must fold into their native conformations to fulfil their biological functions. Failure of proteins to fold leads to cell pathology and a broad range of human diseases referred to as protein misfolding disease, e.g., Alzheimer’s disease, Parkinson’s disease, and type II diabetes. READ MORE

  3. 3. The birth and growth of the protein folding nucleus Studies of protein folding focused on critical contacts, topology and ionic interactions

    University dissertation from Stockholm : Institutionen för biokemi och biofysik

    Author : Linda Hedberg; Stockholms universitet.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein folding; protein stability; two-state folding; chevron plot; transition-state movements; Hammond behaviour; topology; electrostatic interactions; pH dependence; mass-action; protein engineering; pKa; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : Proteins are among the most complex molecules in the cell and they play a major role in life itself. The complexity is not restricted to just structure and function, but also embraces the protein folding reaction. READ MORE

  4. 4. Structural and thermodynamical basis for molecular recognition between engineered binding proteins

    University dissertation from Stockholm : KTH

    Author : Jakob Dogan; KTH.; [2006]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; protein structure; induced fit; binding thermodynamics; NMR spectroscopy; protein engineering; protein-protein interactions; protein stability; calorimetry; TECHNOLOGY Bioengineering Structural biochemistry; TEKNIKVETENSKAP Bioteknik Strukturbiokemi;

    Abstract : The structural determination of interacting proteins, both as individual proteins and in their complex, complemented by thermodynamical studies are vital in order to gain in-depth insights of the phenomena leading to the highly selective protein-protein interactions characteristic of numerous life processes. This thesis describes an investigation of the structural and thermodynamical basis for molecular recognition in two different protein-protein complexes, formed between so-called affibody proteins and their respective targets. READ MORE

  5. 5. From protein sequence to structural instability and disease

    University dissertation from Umeå : Kemiska institutionen

    Author : Lixiao Wang; Umeå universitet.; [2010]
    Keywords : protein domain; remote homologue; intrinsically disorder unstructured proteins; protein function; point mutation; protein family protein stability; HMMs; CRFs; SVMs;

    Abstract : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. READ MORE