Search for dissertations about: "protein targets"
Showing result 1 - 5 of 773 swedish dissertations containing the words protein targets.
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1. Exploring molecular interactions between polypeptide conjugates and protein targets : Manipulating affinity by chemical modifications
Abstract : In this thesis molecular interactions between polypeptide conjugates and protein targets were investigated. Polypeptides were derivatized with small organic molecules, peptides and oligonucleotides. New strategies were developed with the aim to increase affinities for proteins of biological interest. READ MORE
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2. Structural and thermodynamical basis for molecular recognition between engineered binding proteins
Abstract : The structural determination of interacting proteins, both as individual proteins and in their complex, complemented by thermodynamical studies are vital in order to gain in-depth insights of the phenomena leading to the highly selective protein-protein interactions characteristic of numerous life processes. This thesis describes an investigation of the structural and thermodynamical basis for molecular recognition in two different protein-protein complexes, formed between so-called affibody proteins and their respective targets. READ MORE
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3. Systems biology of protein synthesis and secretion in yeast
Abstract : Protein synthesis and secretion is a vital process to maintain cell function. As it demands numerous building blocks, cofactors and chaperones generated from metabolism and translation, the process is intertwined with metabolic and regulatory networks. READ MORE
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4. An evolutionary basis for protein design and structure prediction
Abstract : The sequence diversity of protein families is a result of the biophysical selection pressures that shaped their evolutionary history. Among the dominant pressures is selection for protein thermostability, which in itself is an attractive target in protein engineering because of its importance for various biopharmaceutical properties, the performance of industrial enzymes, and the ability to design new protein functions. READ MORE
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5. Cotranslational protein biogenesis in Escherichia coli monitored by force profile analysis
Abstract : Proteins are a diverse class of biomolecules that carry out many essential functions across all organisms. They can either be found in aqueous compartments or embedded in biological membranes of the cell and are called soluble or membrane proteins, respectively. READ MORE