Search for dissertations about: "protein tyrosine phosphatase"

Showing result 21 - 25 of 53 swedish dissertations containing the words protein tyrosine phosphatase.

  2. 21. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

    Author : Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

    Abstract : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. READ MORE

  4. 22. Specific signaling through heteromeric PDGF receptor complexes

    Author : Simon Ekman; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Platelet-derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal cells and exert its effect by binding to two structurally related receptor tyrosine kinases, denoted α- and β-receptors. PDGF binding induces dimerization of its receptors, both homo-and heterodimerization, leading to their autophosphorylation on tyrosine residues and binding of downstream signaling molecules. READ MORE

  5. 23. Studies on signaling pathways induced by FLT3, an important oncogene in AML

    Author : Elena Razumovskaya; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FLT3; AML; RTK; oncogene; ERK5; hematopoiesis;

    Abstract : FLT3, a receptor tyrosine kinase, is expressed in hematopoietic progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. READ MORE

  6. 24. Antiphagocytosis by Yersinia pseudotuberculosis : role of the YopH target proteins

    Author : Ming Yuan; Maria Fallman; Tommy Nilsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular biology; Cas; Fyb; mAbp1; SKAP-HOM; Yersinia pseudotuberculosis; YopH; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The enteropathogenic bacterium Yersinia pseudotuberculosis binds to β1 integrins on a host cell via its surface protein invasin. This event stimulates signal transduction to the actin cytoskeleton of the eukaryotic cell, which allows the cell to engulf the bacterium that is attached to its surface. However, the pathogen Y. READ MORE

  7. 25. Regulation of PDGFRβ signaling 

    Author : Piotr Wardęga; Johan Lennartsson; Edvard Smith; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PDGF; HD-PTP; Alix; Cbl; Ub; Fer; Y857; Y771; downregulation; degradation; ubiquitination; activation loop; Cell and molecular biology; Cell- och molekylärbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Platelet-derived growth factor (PDGF) isoforms, which bind to closely related a- and b-tyrosine kinase receptors, induce migration, proliferation, survival and differentiation of mesenchymal cells. They signal by the active receptor attracting Src homology 2 (SH2) domain containing proteins, which subsequently initiate a set of signaling pathways. READ MORE