Search for dissertations about: "protein unfolding mass spectrometry"

Showing result 1 - 5 of 6 swedish dissertations containing the words protein unfolding mass spectrometry.

2. 1. Exploring small heat shock protein chaperones by crosslinking mass spectrometry

   Author : Wietske Lambert; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cross-linking; mass spectrometry; protein-protein interactions; Hsp21; BS3; DTSSP; MALDI-TOF TOF; client protein; substrate; aggregation; unfolded protein; chaperone; Small heat shock protein; crosslinking;

   Abstract : Together with other molecular chaperones, small heat shock proteins are key components of the protein quality control system, which is comprised of several hundred proteins and acts to maintain proteome homeostasis in the cell. Small heat shock proteins bind unfolding proteins at an early stage, to prevent these from further unfolding and aggregating. READ MORE

4. 2. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

   Author : Joana Costeira-Paulo; Erik Marklund; Lars Konermann; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; mass spectrometry; dihydroorotate dehydrogenase; alpha-synuclein; protein structure; ion mobility; electrospray ionisation; collision cross section; lipids; gas-phase hydrogen deuterium exchange; collision induced unfolding; Biokemi; Biochemistry;

   Abstract : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. READ MORE

5. 3. Theoretical and Biochemical : Advancing Protein Structure Investigations with Complementing Computations

   Author : Maxim N. Brodmerkel; Erik G. Marklund; Carl Caleman; Charlotte Uetrecht; Helmut Grubmüller; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics simulation; Protein structure; Structural biology; Protein hydration; Electric dipole; Collision Induced Unfolding;

   Abstract : Life as we know it today would not exist without proteins. The functions of proteins for us and other organisms are linked to their three-dimensional structures. As such, protein structure investigations are a crucial contribution for understanding proteins and the molecular basis of life. READ MORE

6. 4. Plant Membrane Proteomics - using isolated membranes and proteins to compare and quantify subproteomes

   Author : Katja Bernfur; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; quantification; proteomics; metabolic labeling; plasma membrane;

   Abstract : Membrane proteins are particularly important to characterize, since they are involved in cellular processes of utmost importance in control and regulation of cells, such as transport across membranes, signal transduction and photosynthesis. The word "proteome" means all proteins expressed by a e.g. READ MORE

7. 5. Processing, stability and interactions of lung surfactant protein C

   Author : Jing Li; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mature SP-C is a 4.2 kDa transmembrane protein which is uniquely expressed in the alveolar type II cell. Human SP-C is generated via multistep proteolytic cleavage of both the C-terminal and Nterminal regions of proSP-C. READ MORE