Search for dissertations about: "protein yield"

Showing result 21 - 25 of 259 swedish dissertations containing the words protein yield.

  2. 21. Polypeptide Conjugates as High-affinity Binders for Proteins

    Author : Lotta Tollstoy Tegler; Lars Baltzer; Amelie Eriksson Karlström; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein recognition; polypeptide conjugates; peptide; molecular interactions; C-reactive protein; Acetylcholine esterase; Human Carboinc anhydrase; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Abstract : A novel concept for protein recognition has been developed. The recognition unit is a hybrid molecule obtained by conjugation of a small organic molecule to a synthetic polypeptide selected from a 16-membered set of 42 amino acid residue sequences. The sequences are unordered and have no prior relation to the target proteins. READ MORE

  4. 22. Protein recognition domains in heparan sulfate

    Author : Emadoldin Feyzi Talarposhti; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; heparin; structure; growth factors; herpes simplex virus; antithrombin; aging; regulation; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Abstract : Heparan sulfate (HS) is a sulfated glycosaminoglycan (GAG) implicated in various physiological and pathological processes such as cell proliferation, viral infection and inhibition of blood coagulation. These effects are due to interactions of HS with proteins. READ MORE

  5. 23. Protein production and purification in structural genomics

    Author : Martin Hammarström; Per-Åke Nygren; Torleif Härd; Helena Berglund; Herman van Tilbeurgh; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Recombinational cloning; Escherichia coli; gene expression; fusion proteins; solubility; circular dichroism; nuclear magnetic resonance; Structural biochemistry; Strukturbiokemi;

    Abstract : The number of gene products available for structural and functional study is increasing at an unprecedented rate as a result of the successful whole genome sequencing projects. Systematic structure determination of proteins on a genomic scale, called structural genomics, can significantly contribute to the field of protein science and to functional annotation of newly identified genes. READ MORE

  6. 24. Structure-based Virtual Screening for Ligands of G Protein-coupled Receptors : Design of Allosteric and Dual-Target Modulators

    Author : Stefanie Kampen; Jens Carlsson; Peter Kolb; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptors; Polypharmacology; Molecular Docking; Structure-based Drug Design; Parkinson’s Disease; Virtual Screening; Allosteric Modulators; Bioinformatics; Bioinformatik;

    Abstract : G protein-coupled receptors (GPCRs) are integral membrane proteins responsible for signal transduction of extracellular stimuli into the cell. Because of their widespread distribution throughout the human body and important roles in physiological processes, GPCRs are prominent drug targets and approximately 34% of all approved drugs interact with members of this superfamily. READ MORE

  7. 25. Chemical and mass spectrometrical methods in protein analysis

    Author : Madalina Oppermann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Sensitive analytical methods are essential in protein studies because of frequently encountered limited sample availability. There is a constant need for optimization of sample preparation and analytical procedures for structural characterization of biomedically relevant proteins. Amino acid sequences can be derived from genomic data. READ MORE