Search for dissertations about: "protein-ligand complexes"

Showing result 1 - 5 of 14 swedish dissertations containing the words protein-ligand complexes.

  1. 1. Chemogenomics: Models of Protein-Ligand Interaction Space

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Helena Strömbergsson; Uppsala universitet.; [2009]
    Keywords : ;

    Abstract : The large majority of the currently used drugs are small molecules that interact with proteins. Understanding protein-ligand recognition is thus central to drug discovery and design. Improved experimental techniques have resulted in an immense growth of drug target information. READ MORE

  2. 2. Computational Studies of Structures and Binding Properties of Protein-Ligand Complexes

    University dissertation from Stockholm, Sweden : KTH Royal Institute of Technology

    Author : Xu Wang; KTH.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Theoretical Chemistry and Biology; Teoretisk kemi och biologi;

    Abstract : Proteins are dynamic structural entities that are involved in many biophysical processes through molecular interactions with their ligands. Protein-ligand interactions are of fundamental importance for computer-aided drug discovery. READ MORE

  3. 3. Structural and functional studies of proteins of medical relevance Protein-ligand complexes in cancer and novel structural folds in bacteria

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Robert Gustafsson; Stockholms universitet.; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; Cancer; MTH1; oxidised nucleotides; MTHFD2; nucleotide metabolism; one-carbon metabolism; Botulism; Botulinum neurotoxin; OrfX; OrfX gene cluster; biokemi; Biochemistry;

    Abstract : X-ray crystallography is a tool for determining the structures of proteins and protein-ligand complexes. In this thesis the method has been employed to study several proteins of medical relevance.Cancer is a terrible disease, severely impacting those affected, as well as their family and friends. READ MORE

  4. 4. Analysis of noncovalent and covalent protein-ligand complexes by electrospray ionisation mass spectrometry

    University dissertation from Stockholm : KTH

    Author : Gustav Sundqvist; KTH.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; noncovalent complex; droplet fission; nano-electrospray ionisation; mass spectrometry; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi;

    Abstract : In this thesis, the application of electrospray ionisation mass spectrometry (ESI-MS) to the analysis of intact proteins is demonstrated. In papers I and II, the use of ESI-MS for the analysis of noncovalent protein-ligand complexes were discussed. READ MORE

  5. 5. Assessment of Computational Methods for Ligand Binding

    University dissertation from Division of Theoretical Chemistry, Department of Chemistry, Lund University

    Author : Paulius Mikulskis; Lunds universitet.; Lund University.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; binding affinities; MM GBSA; MM PBSA; LIE; FEP; TI; BAR; protein-ligand complexes; drug design;

    Abstract : Popular Abstract in English Proteins are a big biological molecules that help cells to function. Proteins play important roles in all vital processes of the living cell, transporting molecules, speeding up chemical reactions, supporting structure of other proteins and the cell, helping the cell to move. Various disease-causing agents (e.g. READ MORE