Search for dissertations about: "proteoglycan"

Showing result 1 - 5 of 98 swedish dissertations containing the word proteoglycan.

  1. 1. Proteoglycan Lectin Domain Interactions in Extracellular Matrix Assembly

    University dissertation from Anders I. Olin, BMC C12, 221 84 LUND, SWEDEN

    Author : Anders Olin; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; crystal structure; network formation; collagen IX; N-glycans; PRELP; cross-linking; fibulin-2; lectin; G3; ECM; proteoglycan;

    Abstract : This thesis focuses on the C-terminal G3 region of the large aggregating proteoglycans that are found in complex with hyaluronan in the extracellular matrix. The G3 region contains a C-type lectin domain that binds different extracellular matrix proteins playing an integral role in tissue organization during development and remodeling. READ MORE

  2. 2. Extracellular Matrix Remodelling-Proteoglycan and collagen turnover in arthritis

    University dissertation from Anette Bjärdahlen, BMC C13, 221 84 Lund, Sweden

    Author : Anette Bjärdahlen; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; collagen; cartilage; myofibroblasts; pannus; proteoglycan; Skeleton; muscle system; rheumatology locomotion; reumatologi; Skelett; muskelsystem;

    Abstract : Rheumatoid arthritis is a chronic, inflammatory and systemic disease characterised by joint destruction and pannus formation. To enlarge the understanding how pannus and granulation tissue are formed two animal models were used; one using cartilage wrapped in cotton and implanted into a rat air pouch (AP) and one where mBSA induced arthritis (AIA) was performed. READ MORE

  3. 3. Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function

    University dissertation from Section of Oncology, Dept of Clinical Sciences

    Author : Anders Wittrup; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LL-37; heparan sulfate; glypican; endocytosis; drug delivery; DNA uptake; Cancer; cell penetrating peptides; non-viral gene delivery; organelle purification; proteoglycan; syndecan.;

    Abstract : Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. READ MORE

  4. 4. Atherogenic lipoproteins and their interaction with proteoglycans

    University dissertation from Göteborg

    Author : Christofer Flood; Göteborgs universitet.; Gothenburg University.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apolipoprotein B; atherosclerosis; LDL; proteoglycan; sPLA2; ; retention;

    Abstract : Atherosclerosis is a multi-factorial disease and its pathogenesis is still unclear. However, accumulating evidence during recent years has led to the concept that subendothelial retention of atherogenic lipoproteins is the initiating event in atherogenesis. READ MORE

  5. 5. Aggrecan fragments as biomarkers in osteoarthritis

    University dissertation from Lund Univerity, Faculty of Medicine, Clinical Sciences Lund, Department of Orthopaedics, SE-221 84 Lund, Sweden

    Author : Staffan Larsson; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protease; Aggrecan; osteoarthritis; proteoglycan; knee injury; biomarker; aggrecanase;

    Abstract : Background: In osteoarthritis (OA) the balance of cartilage matrix synthesis and degradation is disturbed, resulting in a gradual destruction of the articular cartilage. Matrix components released into body fluids by proteolytic cleavage can be used as biomarkers of ongoing processes. READ MORE