Search for dissertations about: "proteome"

Showing result 1 - 5 of 245 swedish dissertations containing the word proteome.

  1. 1. The Membrane Proteome : Evolution, Characteristics and Classification

    Author : Markus Sällman Almén; Helgi Schiöth; Robert Fredriksson; Marc Robinson-Rechavi; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Membrane proteins; Membrane proteome; molecular evolution; GPCRs; Dispanins; IFITM; Medicinsk vetenskap; Medical Science;

    Abstract : Membrane proteins are found in all kingdoms of life and are essential for cellular interactions with the environment. Although a large research effort have been put into this group many membrane proteins remains uncharacterized, both in terms of function and evolutionary history. READ MORE

  2. 2. Mapping the human proteome using bioinformatic methods

    Author : Linn Fagerberg; Mathias Uhlén; Alvis Brazma; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; proteome; transcriptome; bioinformatics; membrane protein prediction; subcellular localization; protein expression level; cell line; immunohistochemistry; immunofluorescence; Bioinformatics; Bioinformatik; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Abstract : The fundamental goal of proteomics is to gain an understanding of the expression and function of the proteome on the level of individual proteins, on the level of defined cell types and on the level of the entire organism. In this thesis, the human proteome is explored using membrane protein topology prediction methods to define the human membrane proteome and by global protein expression profiling, which relies on a complex study of the location and expression levels of proteins in tissues and cells. READ MORE

  3. 3. Proteome wide protein production

    Author : Hanna Tegel; Sophia Hober; Diethard Mattanovich; KTH; []
    Keywords : protein production; Escherichia coli; transcription; promoter; translation; rare codon; high-throughput; screening;

    Abstract : Over a decade after the completion of the human genome, researchers around the world are still wondering what information is hidden in the genome. Although the sequences of all human genes are known, it is still almost impossible to determine much more than the primary protein structure from the coding sequence of a gene. READ MORE

  4. 4. Profiling the cancer proteome

    Author : Sofia Waldemarson; Institutionen för Immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; Biotechnology; Bioteknik; cancerology; oncology; Cytology; iTRAQ; biomarkers; DIGE; two-dimensional gel electrophoresis; Proteomics;

    Abstract : Cancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. READ MORE

  5. 5. Antibody-based subcellular localization of the human proteome

    Author : Marie Skogs; Emma Lundberg; Hans Blom; Cecilia Williams; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Human proteome; Subcellular localization; Organelles; Immunofluorescence; Fixation; Permeabilization; Antibody validation; Biotechnology; Bioteknologi;

    Abstract : This thesis describes the use of antibodies and immunofluorescence for subcellular localization of proteins. The key objective is the creation of an open-source atlas with information on the subcellular location of every human protein. READ MORE