Search for dissertations about: "proteomics, mass spectrometry, lung cancer"

Showing result 1 - 5 of 8 swedish dissertations containing the words proteomics, mass spectrometry, lung cancer.

  2. 1. Cancer proteomics : method development for mass spectrometry based analysis of clinical materials

    Author : Maria Pernemalm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : To improve cancer treatment, biomarkers for diagnostics and therapeutic guidance are desperately needed. Mass spectrometry (MS) based proteomics is one of the most promising methods for biomarker discovery. Clinical materials such as blood and tumor tissue provide an excellent starting material for biomarker discovery studies. READ MORE

  4. 2. Cancer proteomics : characterisation of protein expression in human epithelial tumours

    Author : Ayodele A Alaiya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Two-dimensional gel electrophoresis; protein expression; mass spectrometry; epithelial tumour; heterogeneity;

    Abstract : Defining differences in protein expression between tumour cells of various degrees of malignancy is a first step in the development of markers for tumour diagnosis. In this thesis, the expression of multiple proteins in benign and malignant human ovarian, breast and prostate tumours was examined using two-dimensional gel electrophoresis (2-DE). READ MORE

  5. 3. At the intersection of proteomics and pathology : application of mass spectrometry-based protein quantification to histopathology and antibody validation

    Author : Fabio Socciarelli; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The paradigm of Precision Medicine relies on the molecular stratification of patients to select “the right patient for the right drug”. The genomic approach has tried to answer this question, but large genomic studies have raised more questions than given answers. READ MORE

  6. 4. Cancer proteogenomics : connecting genotype to molecular phenotype

    Author : Ioannis Siavelis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The central dogma of molecular biology describes the one-way road from DNA to RNA and finally to protein. Yet, how this flow of information encoded in DNA as genes (genotype) is regulated in order to produce the observable traits of an individual (phenotype) remains unanswered. Recent advances in high-throughput data, i.e. READ MORE

  7. 5. Signalomics : unsupervised and global strategies to explore mechanisms of radioresistence in lung cancer cells

    Author : Sara Ståhl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : To combat lung cancer (LC) which is the number one cancer associated killer, a combination of surgery, chemotherapy, radiotherapy and targeted agents are currently used. The main subtype of LC, Non small cell lung cancer (NSCLC) unfortunately responds poorly to conventional radiotherapy (RT) for reasons yet only partly understood. READ MORE