Search for dissertations about: "proteomics and metabolomic thesis"

Showing result 1 - 5 of 9 swedish dissertations containing the words proteomics and metabolomic thesis.

  2. 1. Proteomic, metabolomic, and microbiome studies of blood pressure

    Author : Yi-Ting Lin; Johan Sundström; Martin Magnusson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood pressure; hypertension; proteomics; metabolomics; microbiome; molecular epidemiology; Mendelian randomization;

    Abstract : Hypertension is a major risk factor for cardiovascular disease and premature death with a substantial global economic burden. To prevent and treat hypertension, it is crucial to improve our understanding of the pathophysiological mechanisms. Hypertension is a multifactorial condition influenced both by genetic and environmental factors. READ MORE

  4. 2. Proteomics and metabolomics in biological and medical applications

    Author : Liudmila Shiryaeva; Wolfgang P. Schröder; Pernilla Wikström; Peter Roepstroff; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2D-DIGE; biomarkers; cold-acclimation; conifer; freezing tolerance; GC-MS; metabolomics; multiple hypothesis test; multivariate analysis; OPLS-DA; Picea obovata; plasma; prostate cancer; proteomics; ProteoMiner; Siberian spruce;

    Abstract : Biological processes in living organisms consist of a vast number of different molecular networks and interactions, which are complex and often hidden from our understanding. This work is focused on recovery of such details for two quite distant examples: acclimation to extreme freezing tolerance in Siberian spruce (Picea obovata) and detection of proteins associated with prostate cancer. READ MORE

  5. 3. Diffuse large B-cell lymphoma - proteomic and metabolomic studies on prognosis and treatment failure

    Author : Martin Stenson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DLBCL; prognostics; proteomics; metabolomics;

    Abstract : Abstract Background and aim: Every year almost 600 patients in Sweden are diagnosed with diffuse large B-cell lymphoma (DLBCL), the most common lymphoma, and with immunochemotherapy, approximately 60 % are cured. Yet, for patients with primary refractory disease or early relapse, the prognosis is very poor. READ MORE

  6. 4. Applying proteomics and metabolomics for studying human skeletal muscle with a focus on chronic trapezius myalgia

    Author : Jenny Hadrévi; Albert Crenshaw; Fatima Pedrosa-Domellöf; Fredrik Hellström; Bijar Ghafouri; Mary F Barbe; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Trapezius myalgia; proteomics; 2D-DIGE; metabolomics; microdialysate; biopsies; anatomi; Human Anatomy;

    Abstract : Work related musculoskeletal disorders are the dominating causes of reported ill-health in industrialized countries. These chronic pain conditions are one of the most costly public health problems in Europe and North America. READ MORE

  7. 5. Multivariate analyses of proteomic and metabolomic patterns in brain tumors

    Author : Carl Wibom; A Tommy Bergenheim; Henrik Antti; Mikael Johansson; Janne Lehtiö; Umeå universitet; []
    Keywords : glioblastoma; meningioma; proteomics; metabolomics; multivariate analyses; onkologi; Oncology;

    Abstract : Glioblastoma multiforme (GBM) is the most common primary brain tumor. Given the current standard of care, the prognosis for patients diagnosed with this disease is still poor. There consequently exists a need to improve current treatments, as well as to develop new ones. READ MORE