Search for dissertations about: "proteostasis"

Showing result 11 - 15 of 27 swedish dissertations containing the word proteostasis.

  2. 11. Interconnectivity of mitochondrial protein biogenesis and homeostasis

    Author : Carmela Vázquez Calvo; Martin Ott; Jan Riemer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; proteostasis; protein quality control; chaperones; biokemi; Biochemistry;

    Abstract : To ensure correct protein function, the cells are equipped with a tightly regulated network of chaperones that support protein folding and actively participate in protein quality control (PQC) and turnover. Due to the dual origin of the mitochondrial proteome, the cytosolic and mitochondrial PQC networks coordinate to ensure protein import and assembly in the organelle. READ MORE

  4. 12. Proteostasis in Bacillus subtilis : chaperones and stress-response mechanisms

    Author : Judith Matavacas; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein homeostasis; Chaperones; DnaK; trigger factor; Spx; YjbH; Bacillus subtilis;

    Abstract : The maintenance of protein homeostasis, also referred to as proteostasis, is essential for preserving the structural and functional stability of the proteome in living organisms. This involves the precise control of protein synthesis, folding, and degradation. READ MORE

  5. 13. Evaluation of the Endo-Lysosomal System and the Ubiquitin-Proteasome System in Neurodegenerative Diseases

    Author : Simon Sjödin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Parkinson’s disease; frontotemporal dementia; dysfunctional proteostasis; cerebrospinal fluid; mass spectrometry;

    Abstract : Neurodegeneration is the process of neuronal cell loss where the symptoms will reflect the regions affected. Neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementia (FTD) are all characterised by an accumulation of protein aggregates suggesting impaired production or turnover of these proteins. READ MORE

  6. 14. Controlling protein homeostasis through regulation of Heat shock factor 1

    Author : Anna E. Masser; Claes Andréasson; Marie Öhman; David Pincus; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stress; protein homeostasis; molecular chaperones; heat shock response; Hsf1; Hsp70; Saccharomyces cerevisiae; molekylär biovetenskap; Molecular Bioscience;

    Abstract : In order to thrive in a changing environment all organisms need to ensure protein homeostasis (proteostasis). Proteostasis is ensured by the proteostasis system that monitors the folding status of the proteome and regulates cell physiology and gene expression to counteract any perturbations. READ MORE

  7. 15. Degradation and sequestration : cellular strategies to counteract proteotoxic stress

    Author : Shanshan Xu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Maintenance of proteome homeostasis (proteostasis) is essential to preserve cellular function in response to intrinsic and extrinsic stress conditions. This is regulated by the proteostasis network, which is comprised of machineries for protein synthesis, folding, sequestering, and degradation. READ MORE