Search for dissertations about: "proteostasis"

Showing result 16 - 20 of 27 swedish dissertations containing the word proteostasis.

  2. 16. Effects of pharmaceutical modulation of protein aggregation on lifespan in Caenorhabditis elegans

    Author : Ida Klang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aging is accompanied by a disruption in various homeostatic networks including those devoted to maintaining protein conformation and integrity. Collectively this maintenance is referred to protein homeostasis or proteostasis. READ MORE

  4. 17. Caulobacter crescentus folding machines at the interface of inheritance, cell division, and energy metabolism

    Author : Kristen Schroeder; Kristina Jonas; Pierre Genevaux; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chaperones; DnaK; chaperonin; GroESL; protein quality control; protein folding; stress response; cellular aging; cell division; bacterial respiration; Caulobacter crescentus; molekylär biovetenskap; Molecular Bioscience;

    Abstract : All living cells must perform essential biological processes while monitoring and responding to environmental cues. Bacteria are accessible experimental systems in which to study the function of conserved central processes. READ MORE

  5. 18. Tipping the scales in cancer : novel mechanisms of inhibiting protein degradation

    Author : Tatiana A Giovannucci; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein homeostasis (in short, ‘proteostasis’) requires the timely degradation of proteins to retain control on protein quality, amount and function. Two main proteolytic systems, the ubiquitin-proteasome system (UPS) and autophagy, complement each other to fulfill this regulatory role. READ MORE

  6. 19. Induction of the heat-shock response by misfolded proteins

    Author : Anna E. Masser; Claes Andréasson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Cells respond to stress by transcriptional changes intended for stress survival and adaption to further stresses. Heat shock is an intensively studied stress condition that induces in a plethora of physiological changes including increased protein misfolding. READ MORE

  7. 20. Metal homeostasis as critical determinant for cellular fitness

    Author : Jutta Diessl; Sabrina Büttner; Rajini Rao; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metal homeostasis; manganese toxicity; coenzyme Q synthesis; mitochondrial respiration; calcineurin signaling; Pmr1; SPCA1; calcium; survival; caloric restriction; Parkinson’s disease models; proteotoxicity; Pep4; cathepsin D; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. READ MORE