Search for dissertations about: "prothrombin mutation"

Showing result 1 - 5 of 11 swedish dissertations containing the words prothrombin mutation.

2. 1. Factor V Leiden mutation and pregnancy. Haemostasis during pregnancy in non-carriers and carriers of factor V Leiden mutation, with special emphasis on placenta-mediated and venous thromboembolic complications and on blood coagulation and fibrinolysis markers for prediction of complications

   Author : Ulla Kjellberg; Göteborgs universitet; []
   Keywords : Activated protein C; D-dimer; Factor V Leiden; fibrinolysis; haemostasis; obstetric complications; platelet function; pregnancy; prothrombin fragment 1 2; soluble fibrin; Sonoclot; thrombosis;

   Abstract : Factor V Leiden (FVL) mutation elevates the risk of venous thromboembolism (VTE) in general. During pregnancy, the haemostatic balance is changed in the direction of hypercoagulability, resulting in an increased incidence of VTE. 42 women were followed longitudinally during pregnancy and the puerperium. READ MORE

4. 2. Venous thromboembolism. Aspects on risk factors, diagnostic tools and treatment with thrombin inhibition

   Author : Karin Wåhlander; Göteborgs universitet; []
   Keywords : deep vein thrombosis; pulmonary embolism; venous thromboembolism; Factor V Leiden; prothrombin gene G20210A; thrombin inhibition; ximelagatran; melagatran; PT; APTT; D-dimer.;

   Abstract : Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a multifactorial disease. The aims of the present thesis were to investigate Factor V Leiden and prothrombin G20210A mutations as potential risk factors for VTE during and after major surgery, to compare different D-dimer assays and evaluate their usefulness in the diagnosis of DVT, to investigate clinical effects, safety and pharmacokinetic properties of an oral thrombin inhibitor (ximelagatran) when treating VTE and finally to investigate the usefulness of coagulation assays (APTT and PT) during treatment with thrombin inhibition. READ MORE

5. 3. Treatment of deep vein thrombosis and risk of recurrent venous thromboembolism

   Author : Per Lindmarker; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Deep vein thrombosis; pulmonary embolism; low molecular mass heparin; therapy; outpatients; recurrent; risk factors; APC-resistance; factor V G1691A; prothrombin G20210A; side;

   Abstract : A cute deep vein thrombosis (DVT) and pulmonary embolism (PE) are different clinical presentations of the same underlying disease, namely venous thromboembolism (VTE), which is a common and potentially fatal condition. Risk factors associated with the first and probably also subsequent events of VTE are hereditary or acquired. READ MORE

6. 4. Familial thrombophilia : Resistance to activated protein C and protein S deficiency

   Author : Bengt Zöller; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Inherited resistance to activated protein C (APC-resistance) and protein S deficiency are associated with functional impairment of the protein C anticoagulant system, resulting in lifelong hypercoagulability andincreased risk of thrombosis. APC-resistance is the most common genetic cause of thrombosis being present in 20% to 60% of thrombosis patients. READ MORE

7. 5. The regulation of factor Va activity by activated protein C -Importance of the individual activated protein C cleavage sites in factor Va

   Author : Eva Norström; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; activated protein C resistance; activated protein C; Blood coagulation; Factor V;

   Abstract : The subject of this thesis is the activated protein C (APC)-mediated inactivation of factor Va. The activated form of factor V (FVa) is a procoagulant cofactor for Factor Xa (FXa) in the conversion of prothrombin to thrombin. READ MORE