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Showing result 1 - 5 of 356 swedish dissertations matching the above criteria.

2. 1. Free energy calculations of G protein-coupled receptor modulation : New methods and applications

   Author : Willem Jespers; Hugo Gutiérrez-de-Terán; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptor; adenosine receptor; molecular dynamics; free energy perturbation; homology modeling; computer simulations; conformational selectivity; binding free energy.; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. READ MORE

4. 2. Creating Correct Network Protocols

   Author : Oskar Wibling; Joachim Parrow; Parosh Abdulla; Ansgar Fehnker; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; network protocols; formal methods; verification; testing; routing protocols; wireless ad hoc networks; model checking; graph transformation; infinite-state systems; Computer science; Datavetenskap;

   Abstract : Network protocol construction is a complex and error prone task. The challenges originate both from the inherent complexity of developing correct program code and from the distributed nature of networked systems. Protocol errors can have devastating consequences. READ MORE

5. 3. Cancer imaging and image analysis methods in whole-body MRI and PET/MRI

   Author : Therese Sjöholm; Joel Kullberg; Filip Malmberg; Robin Strand; Håkan Ahlström; Einar Heiberg Brandt; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; magnetic resonance imaging; diffusion weighted imaging; positron emission tomography; whole-body imaging; normal atlas; CAR T-cell therapy; lymphoma; medical image analysis; Computerized Image Processing; Datoriserad bildbehandling;

   Abstract : Diagnostic medical imaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) can provide structural and functional assessments of the whole body. This has great value for potentially systemic diseases such as cancer. READ MORE

6. 4. Human factors and wireless network applications : more bits and better bits

   Author : Greger Wikstrand; Lars-Erik Janlert; Jerry Eriksson; Mark Högskolan Dalarna Ekonomi och samhälle Dougherty; Angela Sasse; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Human factors; Mobile multimedia; Access protocols; Computer network performance; Quality of service; Video conferencing; Computer games; Streaming video; Medium access control; Collision detection; Reliable multicast; Computer science; Datavetenskap;

   Abstract : I avhandlingen beskrivs ett hypotetiskt system som kan användas av mobila användare, bland andra taxichaufförer, som exempelvis vill följa en viktig fotbollsmatch. Flera faktorer ställer till problem: Ibland står bilen still och föraren har inget annat att tänka på än matchen. READ MORE

7. 5. Non-Steroidal Anti-Inflammatory Drugs in Cyclooxygenases 1 and 2 : Binding modes and mechanisms from computational methods and free energy calculations

   Author : Yasmin Shamsudin Khan; Johan Åqvist; Hugo Gutiérrez de Terán; Xavier Barril; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molecular dynamics simulations; binding free energy; molecular docking; cyclooxygenase; non-steroidal anti-inflammatory drugs; free energy perturbation; potentials of mean force;

   Abstract : Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of drugs. They target the cyclooxygenases (COX) 1 and 2 to reduce the physiological responses of pain, fever, and inflammation. Due to their role in inducing angiogenesis, COX proteins have also been identified as targets in cancer therapies. READ MORE