Search for dissertations about: "proximity extension assay"

Showing result 21 - 25 of 37 swedish dissertations containing the words proximity extension assay.

  2. 21. Identification of pathophysiological and prognostic biomarkers in different types of myocardial infarction

    Author : Marcus Hjort; Bertil Lindahl; Kai M. Eggers; Helge Rørvik Røsjø; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardial infarction; biomarker; pathophysiology; prognosis; MINOCA; STEMI; NSTEMI; hjärtinfarkt; biomarkör; patofysiologi; prognos; MINOCA; STEMI; NSTEMI; Cardiology; Kardiologi;

    Abstract : The pathophysiological mechanisms of myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) are largely unknown. Analogous, differences in pathobiology between ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) are incompletely understood. READ MORE

  4. 22. Importance of peripheral arterial disease as a risk marker in patients with myocardial infarction

    Author : Birgitta Jönelid; Christina Christersson; Nina Johnston; Bertil Lindahl; Bertil Andrén; Lena Jonasson; Uppsala universitet; []
    Keywords : Coronary heart disease; Peripheral artery disease; Polyvascular disease; Inflammatory biomarkers; TNFR-1; TNFR-2; GDF-15; Cardiovascular events.; Cardiology; Kardiologi;

    Abstract : The purpose of this thesis was to describe the true prevalence of widespread arterial disease in a cohort with patients with a recent myocardial infarction (MI) to find valuable clinical methods to detect these patients. Our aim was also to investigate biomarker relationships with peripheral artery disease (PAD) and the importance of PAD in patients’ long-term outcomes. READ MORE

  5. 23. Molecular Epidemiology of Cardiovascular Disease

    Author : Markus Stenemo; Johan Ärnlöv; Rikard Landberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarkers; ischemic stroke; heart failure; omics; proteomics; metabolomics; epidemiology; risk marker; Epidemiologi; Epidemiology;

    Abstract : Cardiovascular disease is a major cause of morbidity and mortality, with increasing prevalence worldwide.Identification of risk markers may enable improved prevention by targeting high-risk individuals, earlier disease diagnosis and treatment, as well as stratification of disease subtypes with different treatment options, thereby minimizing side effects while increasing success rates. READ MORE

  6. 24. Cyclic peptides as biological tools : Applications for diagnosis and therapeutics in rheumatoid arthritis and COVID-19

    Author : Camilla Eriksson; Ulf Göransson; Sunithi Gunasekera; Christian Becker; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Scaffold peptides; peptide grafting; rheumatoid arthritis; SARS-CoV-2; autoantibodies; peptide synthesis; pharmacognosy;

    Abstract : The overall aims of the projects included in this thesis were to design, synthesize and evaluate cyclic peptide scaffolds grafted with biological epitopes for their ability to bind antibodies in rheumatoid arthritis and COVID-19 sera. One of the main outcomes of this thesis was the observation that scaffold peptides grafted with target epitopes efficiently neutralized anti-citrullinated protein autoantibodies (ACPA) from rheumatoid arthritis patients. READ MORE

  7. 25. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Author : Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Abstract : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. READ MORE