Search for dissertations about: "proximity ligation"
Showing result 11 - 15 of 63 swedish dissertations containing the words proximity ligation.
-
11. Development and Application of Triple Specific Proximity Ligation Assays (3PLA)
Abstract : After the completion of the human genome project the human genome was annotated with the surprisingly small amount of 24 000 (www.ensemble.com) genes. READ MORE
-
12. Making Visible the Proximity Between Proteins
Abstract : Genomic DNA is the template of life - the entity which is characterized by a self-sustaining anatomical development, regulated signaling processes, the ability to reproduce and to respond to stimuli. Through what is classically known as the central dogma, the genome is transcribed into mRNA, which in turn is translated into proteins. READ MORE
-
13. Ligation-mediated Molecular Analysis of Influenza Subtypes, Splicing and Protein Glycosylation
Abstract : Binder-based assays are employed throughout the life sciences. Powerful signal amplification techniques have enabled detection of very rare molecule species diluted in simple buffers. Unspecific binding of primary binders leads to increased background in more complex samples. READ MORE
-
14. Improvements and Applications of in situ Proximity Ligation Assays
Abstract : The cells building up the human body is in constant communication with each other. This communication is done through large complex networks of signaling pathways for inter- and intracellular signal transduction. The signaling activity regulates many important processes, for example cell death, proliferation and differentiation. READ MORE
-
15. Development and Application of Proximity Assays for Proteome Analysis in Medicine
Abstract : Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications. READ MORE