Search for dissertations about: "proximity ligation"
Showing result 6 - 10 of 63 swedish dissertations containing the words proximity ligation.
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6. Visualization of Protein Activity Status in situ Using Proximity Ligation Assays
Abstract : In 2001 the human proteome organization (HUPO) was created with the ambition to identify and characterize all proteins encoded in the human genome according to several criteria; their expression levels in different tissues and under different conditions; the sub-cellular localization; post-translational modifications; interactions, and if possible also the relationship between their structure and function.When the knowledge of different proteins and their potential interactions increases, so does the need for methods able to unravel the nature of molecular processes in cells and organized tissues, and ultimately for clinical use in samples obtained from patients. READ MORE
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7. High Content Analysis of Proteins and Protein Interactions by Proximity Ligation
Abstract : Fundamental to all biological processes is the interplay between biomolecules such as proteins and nucleic acids. Studies of interactions should therefore be more informative than mere detection of expressed proteins. Preferably, such studies should be performed in material that is as biologically and clinically relevant as possible, i.e. READ MORE
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8. Advancing DNA-based proximity methods
Abstract : Cellular functions are governed by intricate chains of interactions between proteins. In order to properly understand cellular biology one must look into, not only protein function, but also its interacting network. READ MORE
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9. Application of Proximity Ligation Assay for Multidirectional Studies on Transforming Growth Factor-β Pathway
Abstract : A comprehensive understanding of how the body and all its components function is essential when this knowledge is exploited for medical purposes. The achievements in biological and medical research during last decades has provided us with the complete human genome and identified signaling pathways that governs the cellular processes that facilitates the development and maintenance of higher order organisms. READ MORE
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10. Application of proximity Ligation for Detection of Proteins, Biomolecular Interactions, and Single Copies of Pathogens
Abstract : Proximity ligation is a recently established technique that can provide answers to questions about the concentration, localization, interactions, modifications and functions of proteins. The method enables sensitive protein measurements with a detection limit in the low femtomolar range in complex biological samples. READ MORE