Search for dissertations about: "pseudocapsids"

Found 2 swedish dissertations containing the word pseudocapsids.

  2. 1. Murine polyomavirus VP1 virus-like particles as vectors for gene therapy and as vaccines against polyomavirus infection and tumors

    Author : Andrea Vlastos Franzén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Polyomavirus; virus-like particles; pseudocapsids; gene therapy; vaccines; tumors;

    Abstract : Murine polyomavirus (MPyV) is a double stranded DNA virus ubiquitous in mice. The virus genome encodes for three transforming antigens that interact with the host cell machinery in order to initiate viral production. The transforming antigens can under certain circumstances when not controlled, e.g. READ MORE

  4. 2. Studies on persistent polyomavirus infection in relation to tumor development and options for vaccine and gene therapy

    Author : Shirin Heidari; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Polyomavirus is a small DNA virus capable of inducing tumors in mice with a defective or an immature immune system. The importance of T-cells in prevention of polyoma-induced tumor development has previously been shown. In this thesis, we wished to elucidate the role of humoral immunity with regard to polyomavirus persistence and tumor development. READ MORE