Search for dissertations about: "pseudouridylation"

Found 3 swedish dissertations containing the word pseudouridylation.

  1. 1. High-resolution phenotypic profiling of a eukaryotic ribosome

    Author : Jonathan Esguerra; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : ribosome; ribosomal protein genes; box C D snoRNA; box H ACA snoRNA; 2’-O-ribose methylation; pseudouridylation; high-resolution phenotypic profiling; chemogenetic profiling; Saccharomyces cerevisiae; rRNA modification;

    Abstract : All living cells contain ribosomes, complex macromolecular assemblies of ribonucleic acid (RNA) and proteins, responsible for synthesizing polypeptides in a process called translation. High-resolution three-dimensional ribosomal structures coupled with biochemical studies have paved the way in understanding the various mechanistic events during protein synthesis. READ MORE

  2. 2. RNA modifications and post-transcriptional control in cancer and stem cells

    Author : Giulia Beneventi; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA modifications; Pseudouridine; 2’-O-methylation; Splicing; Translation; non-coding RNAs; Cancer; Stem cells; Differentiation; Stress response;

    Abstract : Splicing and translation are two of the key steps of post-transcriptional regulation of gene expression. Their tight regulation is essential for development, whereas their deregulation is involved in cancer pathogenesis. Nevertheless, many of the molecular mechanisms controlling these processes are still unknown. READ MORE

  3. 3. RNA-binding proteins in transcription and genome integrity

    Author : Chiara Pederiva; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : For decades, it was believed that RNA was merely an intermediate step between DNA and protein effectors. It is now appreciated that RNA is an extremely versatile molecule that affects almost every aspect inside a cell. READ MORE