Search for dissertations about: "psychiatric genetics"

Showing result 1 - 5 of 36 swedish dissertations containing the words psychiatric genetics.

  2. 1. High-resolution Studies of mRNA Expression in Brain : A Search for Genes Differently Expressed in Schizophrenia

    Author : Anja Castensson; Elena Jazin; Terence Speed; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mRNA; gene expression; real-time RT-PCR; schizophrenia; 5-HT serotonin receptor 2C; brain; psychiatric genetics; Genetik; Clinical genetics; Klinisk genetik;

    Abstract : Gene expression differences between patients and controls can be used to find susceptibility genes and drug targets for a disease. High-resolution strategies are required because the differences between the investigated groups may be small and numerous factors may affect the mRNA quantity. READ MORE

  4. 2. Pawsitive selection : Genetics of dog-human communication

    Author : Mia Persson; Per Jensen; Lina Roth; Dominic Wright; Ádám Miklósi; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Through domestication and recent selection, dogs have evolved a unique set of communicative skills to attract and redirect human attention. These social skills have not been seen to the same extent in socialised wolves and are therefore believed to have a significant genetic basis. READ MORE

  5. 3. Microangiopathies of the human brain b immunohistochemical studies on extracellular matrix components in arterial vessels and endothelin

    Author : Wei Wei Zhang; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Microangiopathy; human brain; hyalinosis; amyloid angiopathy; CADASIL; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Microangiopathies may cause ischemic brain lesions and are of fundamental importance in vascular dementia. Risk factors include high age, hypertension, diabetes and Alzheimer's disease. READ MORE

  6. 4. Methods from Statistical Computing for Genetic Analysis of Complex Traits

    Author : Behrang Mahjani; Sverker Holmgren; Lars Rönnegård; Carl Nettelblad; Silvia Delgado Olabarriaga; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Statistical Computing; QTL mapping; Global Optimization; Linear Mixed Models; Scientific Computing; Beräkningsvetenskap;

    Abstract : The goal of this thesis is to explore, improve and implement some advanced modern computational methods in statistics, focusing on applications in genetics. The thesis has three major directions.First, we study likelihoods for genetics analysis of experimental populations. READ MORE

  7. 5. Epigenetic dysregulation in relation to psychiatric traits in adolescence and adulthood

    Author : Adrian Desai Boström; Helgi B. Schiöth; Daniel Nätt; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; methylome-wide; DNA methylation; hypersexual disorder; microRNA; oxytocin signaling; psychiatry; hsa-miR-4456; microRNA-4456; MIR4456; epigenetic dysregulation; microRNA expression; gene target prediction; epigenetics; suicide; suicide attempt; HPA axis; CRH gene; Epigenetics; Methylation; Adolescent depression; MIR4646; methylome-wide association study; Omega-3; mQTL analysis; GAD1; HDAC3; DAWBA;

    Abstract : Epigenetics has evolved into a key research focus in the field of psychiatry. DNA methylation is the most researched epigenetic mechanism. In paper I-III, 130 and 93 adolescents were randomly recruited at two separate intervals. READ MORE