Search for dissertations about: "pulmonary disorder"

Showing result 1 - 5 of 15 swedish dissertations containing the words pulmonary disorder.

  1. 1. Clinical and genetical studies in cystic fibrosis and pseudohypoaldosteronism

    Author : Charlotta Schaedel; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pseudohypoaldosteronism type 1; cystic fibrosis transmembrane conductance regulator CFTR ; Cystic fibrosis; pulmonary disorder; Pediatrics; epithelial sodium channel ENaC; Pediatri;

    Abstract : Cystic fibrosis (CF) is the most common severe autosomal recessive disorder among Caucasians and is caused by mutations of the chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator) gene. Despite a markedly improved median survival many CF patients still die at a young age. READ MORE

  2. 2. Inflammatory mechansims in pulmonary sarcoidosis

    Author : Mary Berlin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Adhesion molecules; alveolitis; bronchoalveolar lavage; bronchial hyperreactivity; extracellular matrix molecules; extrinsic allergic alveolitis; fibrosis; HLA-DR; sarcoidosis; TCR;

    Abstract : INFLAMMATORY MECHANISMS IN PULMONARY SARCOIDOSIS by Mary Berlin Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden Pulmonary sarcoidosis is an inflammatory disorder of unknown aetiology, characterised by an accumulation of CD4+ T-cells in the alveolar compartment and by granuloma formation and varying degrees of interstitial fibrosis. The initial clinical presentation may either be acute with fever, malaise, arthritis and/or erythema nodosum or insidious with cough, dyspnea, tiredness, and loss of weight. READ MORE

  3. 3. Innate and adaptive immune responses in pulmonary sarcoidosis

    Author : Maria Wikén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Sarcoidosis is an inflammatory disease characterized by formation of granulomas in various organs and tissues. Although it is a systemic disorder, the lungs are commonly affected, and an infiltration of T cells, in particular CD4pos T helper 1 (Th1) cells, is seen in the lower airways. READ MORE

  4. 4. Molecular Targets in Autoimmune Polyendocrine Syndrome Type1 and Their Clinical Implications

    Author : Mohammad Alimohammadi; Olle Kämpe; Anna Lobell; Fredrik Rorsman; Tommy Olsson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; autoantibodies; endocrinology; parathyroid; hypoparathyroidism; Addison s disease; pulmonary symptoms; NALP; NALP5; NLR; KCNRG; Molecular medicine; Molekylär medicin;

    Abstract : Autoimmune diseases occur when the immune system attacks and destroys healthy body tissue. Autoimmunity is known to cause a wide range of disorders, and is suspected to be responsible for many more. Most autoimmune disorders are chronic and cause severe morbidity for the patients, and are also costly for society. READ MORE

  5. 5. T lymphocyte and NK cell function in pulmonary inflammation in sarcoidosis

    Author : Kianoosh Katchar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; T lymphocytes; cytokines; activation markers; chemokine receptors; T regulatory cells; sarcoidosis.;

    Abstract : The focus of this thesis is on the role of T lymphocytes and Natural Killer cells in sarcoidosis, which is an inflammatory interstitial pulmonary disorder of unknown etiology. An accumulation of CD4+ T helper cells in the lungs is a characteristic feature of this disease. READ MORE