Search for dissertations about: "puma"

Showing result 1 - 5 of 10 swedish dissertations containing the word puma.

  2. 1. The impact of Bcl-2 family members on mast cell survival and apoptosis

    Author : Maria Ekoff; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mast cells are long-lived effector cells of the immune system perhaps best known for their involvement in allergic diseases. There are several acute and chronic inflammations where mast cell accumulation, activation and release of mediators are important for the initiation and perpetuation of the inflammation. READ MORE

  4. 2. Active Noise Control in Aircraft : Algorithms and Applications

    Author : Sven Johansson; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; active noise control; feedforward control; filtere-x lms algorithm; complex lms; multichannel system; multiple reference; aircraft; headset;

    Abstract : The thesis consists of five papers which are divided into three main parts. Parts A and B deal with active noise control in a propeller aircraft application, whereas Part C deals with active noise control in a helicopter application. READ MORE

  5. 3. Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies

    Author : Andreas Höglund; Jonas Nilsson; Thomas Helleday; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Myc; DNA damage; Decitabine; Chk1; Chk2; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. READ MORE

  6. 4. Assessment of therapeutic targets in experimental models of Myc-induced lymphoma

    Author : Linus Plym Forshell; Jonas Nilsson; Lars-Gunnar Larsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Myc; Decitabine; Pim kinase; RCAS-tva; Neurobiology; Neurobiologi; molekylärbiologi; Molecular Biology;

    Abstract : The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. READ MORE

  7. 5. Rescue of mutant p53 family members by the low molecular weight compound PRIMA-1MET/ APR-246

    Author : Jinfeng Shen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor p53, guardian of the genome, is induced and activated by cellular stress signals such as DNA damage, hypoxia and activation of oncogenes. p53 upregulates downstream target genes, that are involved in cell cycle arrest, senescence, apoptosis, etc. Mutations in p53 occur frequently (around 50%) in many human tumors. READ MORE